Publication: Epidemiology, microbiology and mortality associated with community-acquired bacteremia innortheast Thailand: a multicenter surveillance study
Accepted Date
2012-12-13
Issued Date
2013
Copyright Date
2013
Resource Type
Language
eng
ISSN
1932-6203 (electronic)
Rights
Mahidol University
Rights Holder(s)
Plos One
Bibliographic Citation
Kanoksil M, Jatapai A, Peacock SJ, Limmathurotsakul D. Epidemiology,microbiology and mortality associated with community-acquired bacteremia in northeast Thailand: a multicenter surveillance study. PLoS One. 2013;8(1):e54714.
Suggested Citation
Manas Kanoksil, Anchalee Jatapai, อัญชลี เจตะภัย, Peacock, Sharon J., Direk Limmathurotsakul, ดิเรก ลิ้มมธุรสกุล Epidemiology, microbiology and mortality associated with community-acquired bacteremia innortheast Thailand: a multicenter surveillance study. Kanoksil M, Jatapai A, Peacock SJ, Limmathurotsakul D. Epidemiology,microbiology and mortality associated with community-acquired bacteremia in northeast Thailand: a multicenter surveillance study. PLoS One. 2013;8(1):e54714.. doi:10.1371/journal.pone.0054714 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/747
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Title
Epidemiology, microbiology and mortality associated with community-acquired bacteremia innortheast Thailand: a multicenter surveillance study
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Abstract
BACKGROUND: National statistics in developing countries are likely to underestimate deaths due to bacterial infections. Here, we calculated mortality associated with community-acquired bacteremia (CAB) in a developing country using
routinely available databases.
METHODS/PRINCIPAL FINDINGS: Information was obtained from the microbiology and
hospital database of 10 provincial hospitals in northeast Thailand, and compared
with the national death registry from the Ministry of Interior, Thailand for the
period between 2004 and 2010. CAB was defined in patients who had pathogenic
organisms isolated from blood taken within 2 days of hospital admission without a
prior inpatient episode in the preceding 30 days. A total of 15,251 CAB patients
identified, of which 5,722 (37.5%) died within 30 days of admission. The
incidence rate of CAB between 2004 and 2010 increased from 16.7 to 38.1 per
100,000 people per year, and the mortality rate associated with CAB increased
from 6.9 to 13.7 per 100,000 people per year. In 2010, the mortality rate
associated with CAB was lower than that from respiratory tract infection, but
higher than HIV disease or tuberculosis. The most common causes of CAB were
Escherichia coli (23.1%), Burkholderia pseudomallei (19.3%), and Staphylococcus
aureus (8.2%). There was an increase in the proportion of Extended-Spectrum
Beta-Lactamases (ESBL) producing E. coli and Klebsiella pneumoniae over time.
CONCLUSIONS: This study has demonstrated that national statistics on causes of
death in developing countries could be improved by integrating information from
readily available databases. CAB is neglected as an important cause of death, and
specific prevention and intervention is urgently required to reduce its incidence
and mortality.