Publication: Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo
Issued Date
2004-05-02
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ISSN
03784274
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2-s2.0-1942517470
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Mahidol University
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SCOPUS
Bibliographic Citation
Toxicology Letters. Vol.150, No.3 (2004), 259-269
Suggested Citation
Thida Chanyachukul, Krongtong Yoovathaworn, Watchareewan Thongsaard, Sukumal Chongthammakun, Panida Navasumrit, Jutamaad Satayavivad Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo. Toxicology Letters. Vol.150, No.3 (2004), 259-269. doi:10.1016/j.toxlet.2004.02.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21804
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Title
Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo
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Abstract
Alterations of motor behavioral patterns and monoamine contents in the discrete rat brain areas after acute paraquat exposure (3, 5, 10, 20mg/kg, s.c.) have been studied. The results showed that paraquat at the doses of 5, 10, and 20mg/kg significantly reduced locomotive, stereotypic, and rotational behaviors. Significant decreases of norepinephrine (NE) contents in cortex and hypothalamus, as well as striatal contents of dopamine (DA) and its acidic metabolites, were detected. In addition, L-valine (200mg/kg, i.p.) significantly attenuated paraquat-induced toxicity at moderate dose (5mg/kg) but not at high dose (20mg/kg). The results provide evidence that paraquat can enter the brain as illustrated by the alterations in the motor behavioral pattern and neurochemical contents. Furthermore, the attenuation effect of L-valine against systemic administration of paraquat-induced motor behaviors was detected, with a slightly protective effect on paraquat-induced neurochemical alterations. © 2004 Elsevier Ireland Ltd. All rights reserved.