Publication: Olanzapine pharmacokinetics are similar in Chinese and Caucasian subjects
Issued Date
2003-08-01
Resource Type
ISSN
03065251
Other identifier(s)
2-s2.0-0042530223
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Mahidol University
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SCOPUS
Bibliographic Citation
British Journal of Clinical Pharmacology. Vol.56, No.2 (2003), 184-187
Suggested Citation
Korbtham Sathirakul, Clark Chan, Leyan Teng, Richard F. Bergstrom, Kwee Poo Yeo, Stephen D. Wise Olanzapine pharmacokinetics are similar in Chinese and Caucasian subjects. British Journal of Clinical Pharmacology. Vol.56, No.2 (2003), 184-187. doi:10.1046/j.1365-2125.2003.01857.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21029
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Title
Olanzapine pharmacokinetics are similar in Chinese and Caucasian subjects
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Abstract
Aim: To compare the pharmacokinetic profiles and dose proportionality of olanzapine in Chinese and Caucasian subjects. Methods: Randomized, three-period study with 12 Chinese and 12 Caucasian, healthy, male subjects administered 2.5, 5 and 10 mg olanzapine. Noncompartmental pharmacokinetic parameters were derived. Results: No statistically significant racial differences in the weight-normalized pharmacokinetic parameters were observed except for Vz/Fnorm, which was 17% lower at the 5- and 10-mg dose in the Chinese group (95% confidence interval 8.49, 10.1 and 8.05, 9.73, respectively), compared with the Caucasian group (9.53, 12.8 and 9.39, 12.0, respectively). Olanzapine's pharmacokinetics were linear and dose proportional in both racial groups. Conclusion: The pharmacokinetics of olanzapine are similar in both Chinese and Caucasian racial groups.