Publication: The eosinophilic response and haematological recovery after treatment for Plasmodium falciparum malaria
Issued Date
1999-08-16
Resource Type
ISSN
13602276
Other identifier(s)
2-s2.0-0032796484
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tropical Medicine and International Health. Vol.4, No.7 (1999), 471-475
Suggested Citation
Luis H. Camacho, Polarat Wilairatana, Günter Weiss, Marco A. Mercader, Gary M. Brittenham, Sornchai Looareesuwan, Victor R. Gordeuk The eosinophilic response and haematological recovery after treatment for Plasmodium falciparum malaria. Tropical Medicine and International Health. Vol.4, No.7 (1999), 471-475. doi:10.1046/j.1365-3156.1999.00426.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25434
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Title
The eosinophilic response and haematological recovery after treatment for Plasmodium falciparum malaria
Abstract
To examine a possible relationship between the immune response and haematological recovery after acute falciparum malaria, we followed peripheral blood eosinophil counts and haemoglobin concentrations for 4 weeks after starting effective treatment in 70 adult Thai patients. Eosinophils are induced by Th-2 cytokines as well as other stimuli. Eosinophil counts were elevated in only 8 (11%) of the subjects at presentation, but were increased in 65 (93%) by day 7. Eosinophil counts then decreased markedly by day 14, followed by a second increase until day 28. A significant positive correlation was found between peak eosinophil counts on day 7 and the haemoglobin concentration on day 28, both in 16 subjects without stool parasites (r = 0.65, P = 0.006) and in 54 patients with stool parasites (r = 0.32; P = 0.0019). These results suggest that a robust eosinophilic response shortly after completing antimalarial therapy predicts a good recovery from malaria-associated anaemia.