Publication: The murine cerebral malaria phenomenon
Issued Date
2010-01-01
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ISSN
14714922
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2-s2.0-72449164590
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Mahidol University
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SCOPUS
Bibliographic Citation
Trends in Parasitology. Vol.26, No.1 (2010), 11-15
Suggested Citation
Nicholas J. White, Gareth D H Turner, Isabelle M. Medana, Arjen M. Dondorp, Nicholas P J Day The murine cerebral malaria phenomenon. Trends in Parasitology. Vol.26, No.1 (2010), 11-15. doi:10.1016/j.pt.2009.10.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29289
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Title
The murine cerebral malaria phenomenon
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Abstract
P.berghei ANKA infection in CBA or CB57BL/6 mice is used widely as a murine 'model' of human cerebral malaria (HCM), despite markedly different histopathological features. The pathology of the murine model is characterised by marked inflammation with little or no intracerebral sequestration of parasitised erythrocytes, whereas HCM is associated with intense intracerebral sequestration, often with little inflammatory response. There are now more than ten times as many studies each year of the murine model than on HCM. Of 48 adjunctive interventions evaluated in the murine model, 44 (92%) were successful, compared with only 1 (6%) of 17 evaluated in HCM during the same period. The value of the mouse model in identifying pathological processes or therapeutic interventions in human cerebral malaria is questionable. © 2009 Elsevier Ltd. All rights reserved.