Publication: Dependence of pharmacokinetics and biodistribution on polymer architecture: Effect of cyclic versus Linear polymers
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Issued Date
2009-03-25
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ISSN
00027863
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2-s2.0-67849104970
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the American Chemical Society. Vol.131, No.11 (2009), 3842-3843
Suggested Citation
Norased Nasongkia, Bo Chen, Nichole Macaraeg, Megan E. Fox, Jean M.J. Fréchet, Francis C. Szoka Dependence of pharmacokinetics and biodistribution on polymer architecture: Effect of cyclic versus Linear polymers. Journal of the American Chemical Society. Vol.131, No.11 (2009), 3842-3843. doi:10.1021/ja900062u Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27263
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Title
Dependence of pharmacokinetics and biodistribution on polymer architecture: Effect of cyclic versus Linear polymers
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Abstract
The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable molecular weight. © 2009 American Chemical Society.