Publication: Antioxidant activity and antiapoptotic effect of Asparagus racemosus root extracts in human lung epithelial h460 cells
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Issued Date
2011-01-01
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ISSN
17921015
17920981
17920981
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2-s2.0-78751627340
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Mahidol University
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SCOPUS
Bibliographic Citation
Experimental and Therapeutic Medicine. Vol.2, No.1 (2011), 143-148
Suggested Citation
Lalana Kongkaneramit, Wasu Witoonsaridsilp, Penchom Peungvicha, Kornkanok Ingkaninan, Neti Waranuch, Narong Sarisuta Antioxidant activity and antiapoptotic effect of Asparagus racemosus root extracts in human lung epithelial h460 cells. Experimental and Therapeutic Medicine. Vol.2, No.1 (2011), 143-148. doi:10.3892/etm.2010.172 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11627
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Title
Antioxidant activity and antiapoptotic effect of Asparagus racemosus root extracts in human lung epithelial h460 cells
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Abstract
The present study examined the antioxidant activity and protective effect of extracts from Asparagus racemosus roots against Lipofectamine-induced apoptosis. Five fractions from a successive extraction process ranging from non-polar to more polar solvents were obtained. The total saponin content as a marker in terms of diosgenin equivalent value of the root extracts was found to be in the range of 240-420μg/mg extract, with higher values for the ethanol and aqueous fractions. The antioxidant activity measured using the DPPH method in terms of mean effective concentration (EC50) of the aqueous fraction was found to be 600 μg/ml as compared to 1.5 μg/ml of ascorbic acid. It is proposed that Asparagus racemosus root extracts effectively inhibit Lipofectamine-induced apoptosis by their protective effect, and may serve as an advantageous alternative option for gene delivery.