Publication: A novel SR protein binding site in a cis-regulatory element of HIV-1
| dc.contributor.author | Ornpreya Suptawiwat | en_US |
| dc.contributor.author | Chompunuch Boonarkart | en_US |
| dc.contributor.author | Prasert Auewarakul | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-09-24T09:03:52Z | |
| dc.date.available | 2018-09-24T09:03:52Z | |
| dc.date.issued | 2010-11-01 | en_US |
| dc.description.abstract | We have previously described a cis enhancing sequence (CES) in the gp41 region of the HIV-1 env gene. It could enhance HIV-1 Gag expression via both rev-dependent and CTE (constitutive transport element)-dependent pathways. We identified a functionally important and conserved region in the CES that contained a predicted binding sequence for an SR protein, ASF/SF2. We show here that ASF/SF2 bound to this sequence in an electrophoretic mobility shift assay and that the putative ASF/SF2-binding sequence was required for the enhancement of Gag expression by CES and might play a role in HIV-1 posttranscriptional regulation. © 2010 Springer-Verlag. | en_US |
| dc.identifier.citation | Archives of Virology. Vol.155, No.11 (2010), 1789-1795 | en_US |
| dc.identifier.doi | 10.1007/s00705-010-0765-2 | en_US |
| dc.identifier.issn | 03048608 | en_US |
| dc.identifier.other | 2-s2.0-78149411486 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/29179 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78149411486&origin=inward | en_US |
| dc.subject | Immunology and Microbiology | en_US |
| dc.title | A novel SR protein binding site in a cis-regulatory element of HIV-1 | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78149411486&origin=inward | en_US |