Publication: Rickettsial illnesses as important causes of febrile illness in Chittagong, Bangladesh
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Issued Date
2018-04-01
Resource Type
ISSN
10806059
10806040
10806040
Other identifier(s)
2-s2.0-85044246696
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Mahidol University
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SCOPUS
Bibliographic Citation
Emerging Infectious Diseases. Vol.24, No.4 (2018), 638-645
Suggested Citation
Hugh W. Kingston, Mosharraf Hossain, Stije Leopold, Tippawan Anantatat, Ampai Tanganuchitcharnchai, Ipsita Sinha, Katherine Plewes, Richard J. Maude, M. A. Hassan Chowdhury, Sujat Paul, Rabiul Alam Mohammed Erfan Uddin, Mohammed Abu Naser Siddiqui, Abu Shahed Md Zahed, Abdullah Abu Sayeed, Mohammed Habibur Rahman, Anupam Barua, Mohammed Jasim Uddin, Mohammed Abdus Sattar, Arjen M. Dondorp, Stuart D. Blacksell, Nicholas P.J. Day, Aniruddha Ghose, Amir Hossain, Daniel H. Paris Rickettsial illnesses as important causes of febrile illness in Chittagong, Bangladesh. Emerging Infectious Diseases. Vol.24, No.4 (2018), 638-645. doi:10.3201/eid2404.170190 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/46804
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Title
Rickettsial illnesses as important causes of febrile illness in Chittagong, Bangladesh
Author(s)
Hugh W. Kingston
Mosharraf Hossain
Stije Leopold
Tippawan Anantatat
Ampai Tanganuchitcharnchai
Ipsita Sinha
Katherine Plewes
Richard J. Maude
M. A. Hassan Chowdhury
Sujat Paul
Rabiul Alam Mohammed Erfan Uddin
Mohammed Abu Naser Siddiqui
Abu Shahed Md Zahed
Abdullah Abu Sayeed
Mohammed Habibur Rahman
Anupam Barua
Mohammed Jasim Uddin
Mohammed Abdus Sattar
Arjen M. Dondorp
Stuart D. Blacksell
Nicholas P.J. Day
Aniruddha Ghose
Amir Hossain
Daniel H. Paris
Mosharraf Hossain
Stije Leopold
Tippawan Anantatat
Ampai Tanganuchitcharnchai
Ipsita Sinha
Katherine Plewes
Richard J. Maude
M. A. Hassan Chowdhury
Sujat Paul
Rabiul Alam Mohammed Erfan Uddin
Mohammed Abu Naser Siddiqui
Abu Shahed Md Zahed
Abdullah Abu Sayeed
Mohammed Habibur Rahman
Anupam Barua
Mohammed Jasim Uddin
Mohammed Abdus Sattar
Arjen M. Dondorp
Stuart D. Blacksell
Nicholas P.J. Day
Aniruddha Ghose
Amir Hossain
Daniel H. Paris
Abstract
© 2018, Centers for Disease Control and Prevention (CDC). All rights reserved. We conducted a yearlong prospective study of febrile patients admitted to a tertiary referral hospital in Chittagong, Bangladesh, to assess the proportion of patients with rickettsial illnesses and identify the causative pathogens, strain genotypes, and associated seasonality patterns. We diagnosed scrub typhus in 16.8% (70/416) and murine typhus in 5.8% (24/416) of patients; 2 patients had infections attributable to undifferentiated Rickettsia spp. and 2 had DNA sequence-confirmed R. felis infection. Orientia tsutsugamushi genotypes included Karp, Gilliam, Kato, and TA763-like strains, with a prominence of Karp-like strains. Scrub typhus admissions peaked in a biphasic pattern before and after the rainy season, whereas murine typhus more frequently occurred before the rainy season. Death occurred in 4% (18/416) of cases; case-fatality rates were 4% each for scrub typhus (3/70) and murine typhus (1/28). Overall, 23.1% (96/416) of patients had evidence of treatable rickettsial illnesses, providing important evidence toward optimizing empirical treatment strategies.