Publication: Association of atopic dermatitis with an increased risk of systemic lupus erythematosus: A systematic review and meta-analysis
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Issued Date
2021-07-01
Resource Type
ISSN
09722823
00223859
00223859
Other identifier(s)
2-s2.0-85113919199
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Postgraduate Medicine. Vol.67, No.3 (2021), 139-145
Suggested Citation
B. Ponvilawan, N. Charoenngam, W. Wongtrakul, P. Ungprasert Association of atopic dermatitis with an increased risk of systemic lupus erythematosus: A systematic review and meta-analysis. Journal of Postgraduate Medicine. Vol.67, No.3 (2021), 139-145. doi:10.4103/jpgm.JPGM_1270_20 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78052
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Title
Association of atopic dermatitis with an increased risk of systemic lupus erythematosus: A systematic review and meta-analysis
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Abstract
Context: Previous studies on the association between atopic dermatitis (AD) and systemic lupus erythematosus (SLE) have yielded inconsistent results. Aims: To investigate the relationship between atopic dermatitis and systemic lupus erythematosus. Settings and Design: Systematic review and meta-analysis. Materials and Methods: A systematic review was conducted on EMBASE and MEDLINE databases from inception to March 2020 using a search strategy that consisted of terms related to AD and SLE. Eligible study must be either cohort or case-control study. For cohort studies, they must include patients with AD and comparators without AD, then follow them for incident SLE. For case-control studies, they must include cases with SLE and controls without SLE and examine their prior history of AD. Statistical Analysis Used: Meta-analysis of the studies was performed using a random-effect, generic inverse variance method to combine effect estimate and standard error. Funnel plot was used to assess publication bias. Results: A total of 21,486 articles were retrieved. After two rounds of review by three investigators, six case-control studies were qualified for the meta-analysis. The case-control study meta-analysis found a significantly increased odds of SLE among patients with AD with the pooled odds ratio of 1.46 (95% CI, 1.05-2.04). Conclusions: A significant association between AD and increased odds of SLE was observed by this systematic review and meta-analysis.