Publication:
DIFFERENTIATION OF METABOLIC ADRENOCEPTORS

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dc.contributor.authorT. LOAKPRADITen_US
dc.contributor.authorR. LOCKWOODen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-03-22T09:30:54Z
dc.date.available2018-03-22T09:30:54Z
dc.date.issued1977-01-01en_US
dc.description.abstractCardiovascular and metabolic responses to intravenous infusion of isoprenaline were measured in fasted, anaesthetized cats. Isoprenaline (0.2 μg kg −1 min −1 for 15 min) decreased diastolic blood pressure and increased heart rate, blood glucose, blood lactate and plasma free fatty acids. Oxprenolol (0.5 mg/kg) antagonized all cardiovascular and metabolic effects of isoprenaline non‐selectively. Para‐oxprenolol (0.25 mg/kg) and practolol (4 mg/kg) antagonized the effects of isoprenaline on heart rate and free fatty acids selectively. H 35/25 ((1‐(4‐methylphenyl)‐2‐isopropyl aminopropanol) hydrochloride, 3 mg/kg) antagonized the effects of isoprenaline on blood pressure, glucose and lactate selectively. It is concluded that metabolic adrenoceptors are differentiated into subtypes similar to those mediating cardiostimulation and vasodilatation. 1977 British Pharmacological Societyen_US
dc.identifier.citationBritish Journal of Pharmacology. Vol.59, No.1 (1977), 135-140en_US
dc.identifier.doi10.1111/j.1476-5381.1977.tb06987.xen_US
dc.identifier.issn14765381en_US
dc.identifier.issn00071188en_US
dc.identifier.other2-s2.0-0017365208en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/10337
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017365208&origin=inwarden_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleDIFFERENTIATION OF METABOLIC ADRENOCEPTORSen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017365208&origin=inwarden_US

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