Publication: Establishment of MUi009 – A human induced pluripotent stem cells from a 32 year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2
Issued Date
2017-04-01
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18767753
18735061
18735061
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2-s2.0-85015405232
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Mahidol University
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SCOPUS
Bibliographic Citation
Stem Cell Research. Vol.20, (2017), 80-83
Suggested Citation
Wasinee Wongkummool, Warun Maneepitasut, Pirut Tong-ngam, Amornrat Tangprasittipap, Thongperm Munkongdee, Chanikarn Boonchuay, Saovaros Svasti, Narisorn Kitiyanant, Kittiphong Paiboonsukwong, Suthat Fucharoen, Alisa Tubsuwan Establishment of MUi009 – A human induced pluripotent stem cells from a 32 year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2. Stem Cell Research. Vol.20, (2017), 80-83. doi:10.1016/j.scr.2017.02.012 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41876
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Title
Establishment of MUi009 – A human induced pluripotent stem cells from a 32 year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2
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Abstract
© 2017 The Authors The thalassemias are a group of genetic disorders characterized by a deficiency in the synthesis of globin chains. In this study the MUi009-A human induced pluripotent stem cell line was successfully generated from peripheral blood CD34 + haematopoietic progenitors of a 32 year old male who had coinherited a homozygous β°-thalassemia mutation at codon 41/42 (-TCTT) and a heterozygous α-thalassemia 4.2 deletion. The MUi009-A cell line exhibited embryonic stem cell characteristics with consistent pluripotency marker expression and the capability of differentiating into the three germ layers. The cell line may provide a tool for drug testing and gene therapy studies.