Publication: Anti-metastatic effects of curcusone B, a diterpene from Jatropha curcas
Issued Date
2005-01-01
Resource Type
ISSN
0258851X
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2-s2.0-16244374976
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Mahidol University
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SCOPUS
Bibliographic Citation
In Vivo. Vol.19, No.1 (2005), 265-268
Suggested Citation
Surin Muangman, Montri Thippornwong, Rutaiwan Tohtong Anti-metastatic effects of curcusone B, a diterpene from Jatropha curcas. In Vivo. Vol.19, No.1 (2005), 265-268. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16388
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Title
Anti-metastatic effects of curcusone B, a diterpene from Jatropha curcas
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Abstract
A new approach to cancer therapy in recent years has been to target the metastatic process. The anti-metastatic potential of curcusone B, a diterpene isolated from Jatropha curcas Linn. (Euphorbiaceae), a herbal plant that has been used in traditional folk medicine in many tropical countries, was investigated against 4 human cancer cell lines. Treatment with non-cytotoxic doses of curcusone B resulted in a strong reduction of in vitro invasion, motility and secretion of matrix-metalloproteinases (MMP) of the cancer cells, whereas the ability to adhere to a Matrigel-coated surface was variably sensitive to curcusone B treatment. Curcusone B, thus, effectively suppresses the metastatic processes at doses that are non-toxic to cells, which may be of therapeutic benefit for the treatment of metastatic cancers.