Publication: Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand
Issued Date
2004-03-15
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ISSN
00221899
DOI
Other identifier(s)
2-s2.0-1642328392
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.189, No.6 (2004), 1052-1055
Suggested Citation
Kesinee Chotivanich, Juntima Sritabal, Rachanee Udomsangpetch, Paul Newton, Katarzyna A. Stepniewska, Ronatrai Ruangveerayuth, Sornchai Looareesuwan, David J. Roberts, Nicholas J. White Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand. Journal of Infectious Diseases. Vol.189, No.6 (2004), 1052-1055. doi:10.1086/381900 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21688
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Title
Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand
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Abstract
The relationship of the platelet-mediated autoagglutination of Plasmodium fakiparum-infected red blood cells (IRBCs) to disease severity was investigated in 182 Thai patients with falciparum malaria; it was evident in 43% of uncomplicated malaria (n = 63), 41% of severe malaria (n = 104), and 100% of cerebral malaria (n = 15; P = .001) isolates. The median (range) number of IRBCs in agglutinates per 1000 IRBCs was significantly higher in cerebral malaria (6 [3-42]) than in severe (0 [0-52]) and uncomplicated (0 [0-24]) malaria (P = .01). In multivariate analyses, high parasitemia and cerebral malaria were associated independently with parasite agglutination.