Publication: Association of Time–Varying Intensity of Ventilation With Mortality in Patients With COVID−19 ARDS: Secondary Analysis of the PRoVENT–COVID Study
Issued Date
2021-11-18
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ISSN
2296858X
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2-s2.0-85120617322
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Mahidol University
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SCOPUS
Bibliographic Citation
Frontiers in Medicine. Vol.8, (2021)
Suggested Citation
Michiel T.U. Schuijt, David M.P. van Meenen, Ignacio Martin–Loeches, Guido Mazzinari, Marcus J. Schultz, Frederique Paulus, Ary Serpa Neto Association of Time–Varying Intensity of Ventilation With Mortality in Patients With COVID−19 ARDS: Secondary Analysis of the PRoVENT–COVID Study. Frontiers in Medicine. Vol.8, (2021). doi:10.3389/fmed.2021.725265 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77663
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Title
Association of Time–Varying Intensity of Ventilation With Mortality in Patients With COVID−19 ARDS: Secondary Analysis of the PRoVENT–COVID Study
Other Contributor(s)
Melbourne Medical School
Hogeschool van Amsterdam, University of Applied Sciences
Hospital Universitari i Politècnic La Fe
Monash University
Hospital Israelita Albert Einstein
Mahidol University
Nuffield Department of Medicine
Austin Hospital
St James's Hospital
Amsterdam UMC - University of Amsterdam
Hogeschool van Amsterdam, University of Applied Sciences
Hospital Universitari i Politècnic La Fe
Monash University
Hospital Israelita Albert Einstein
Mahidol University
Nuffield Department of Medicine
Austin Hospital
St James's Hospital
Amsterdam UMC - University of Amsterdam
Abstract
Background: High intensity of ventilation has an association with mortality in patients with acute respiratory failure. It is uncertain whether similar associations exist in patients with acute respiratory distress syndrome (ARDS) patients due to coronavirus disease 2019 (COVID−19). We investigated the association of exposure to different levels of driving pressure (ΔP) and mechanical power (MP) with mortality in these patients. Methods: PRoVENT–COVID is a national, retrospective observational study, performed at 22 ICUs in the Netherlands, including COVID−19 patients under invasive ventilation for ARDS. Dynamic ΔP and MP were calculated at fixed time points during the first 4 calendar days of ventilation. The primary endpoint was 28–day mortality. To assess the effects of time–varying exposure, Bayesian joint models adjusted for confounders were used. Results: Of 1,122 patients included in the PRoVENT–COVID study, 734 were eligible for this analysis. In the first 28 days, 29.2% of patients died. A significant increase in the hazard of death was found to be associated with each increment in ΔP (HR 1.04, 95% CrI 1.01–1.07) and in MP (HR 1.12, 95% CrI 1.01–1.36). In sensitivity analyses, cumulative exposure to higher levels of ΔP or MP resulted in increased risks for 28–day mortality. Conclusion: Cumulative exposure to higher intensities of ventilation in COVID−19 patients with ARDS have an association with increased risk of 28–day mortality. Limiting exposure to high ΔP or MP has the potential to improve survival in these patients. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT04346342.