Publication: Review: Molecular basis of MNS blood group variants
Issued Date
2006-12-01
Resource Type
ISSN
0894203X
Other identifier(s)
2-s2.0-33846906872
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Immunohematology. Vol.22, No.4 (2006), 171-182
Suggested Citation
P. Palacajornsuk Review: Molecular basis of MNS blood group variants. Immunohematology. Vol.22, No.4 (2006), 171-182. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23430
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Review: Molecular basis of MNS blood group variants
Author(s)
Other Contributor(s)
Abstract
The MNS blood group antigens are expressed in the RBC membrane on glycophorin A (GPA), glycophorin B (GPB), or combinations of both. GPA expresses the M or N antigen, whereas GPB expresses the S or s antigen and the N antigen ('N'). Both glycophorin genes (GYPA and GYPB) are located on the long arm of chromosome 4 and share 95 percent sequence identity. This high degree of sequence identity, together with the rare involvement of a third homologous gene (GYPE), provides an increased chance of recombination, resulting in hybrid molecules that often carry one or more novel antigens. Some of the antigens in the MNS system result from a single nucleotide substitution. The MNS blood group system now consists of more than 40 distinct antigens. This review summarizes the molecular basis associated with some of the antigens in the MNS blood group system.