Publication: Guided Haversian remodeling in acute bone trauma in rabbit ribia and mandible
Issued Date
2007-08-10
Resource Type
ISSN
16710282
Other identifier(s)
2-s2.0-34548085647
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Mahidol University
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SCOPUS
Bibliographic Citation
Chinese Journal of Emergency Medicine. Vol.16, No.8 (2007), 789-794
Suggested Citation
Hong He, Jian Qi Huang, Fei Yun Ping, Terapat Hitiwan Guided Haversian remodeling in acute bone trauma in rabbit ribia and mandible. Chinese Journal of Emergency Medicine. Vol.16, No.8 (2007), 789-794. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24785
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Title
Guided Haversian remodeling in acute bone trauma in rabbit ribia and mandible
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Abstract
Objective: To search a better novae biomaterial applied to guide bone regeneration for promoting the healing of acute bone trauma by the experimental study of Haversian remodeling. Method: Circular bone defects of 5mm diameter were created in tibias and the corners of mandibles in 36 rabbits. The defects were covered with calcium alginate film (CAF) in the experimental group, collagen membrane (CM) and no membrane (blank) in the control groups respectively. Healing conditions were analyzed using gross inspection, and histological and immunohistochemical studies after 1, 2, 4, 6 and 8 weeks respectively. Results: The experimental group appeared more and earlier Haversian remodeling with osteoinductive factors leading to better bone regeneration. The control groups showed more macrophages with CM absorbed slowly, weak and delayed Haversian remodeling, and less osteoinductive factors (P < 0.05) in the early stage. Conclusions: Calcium alginate film, as a relatively cheaper biomaterial, provided better effect than the collagen membrane on guided bone regeneration, because of its better Haversian remodeling and more content of osteoinductive factors shown in this experiment.