Publication: Application of polysaccharide microarray technology for the serodiagnosis of Burkholderia pseudomallei infection (melioidosis) in humans
Issued Date
2008-01-01
Resource Type
ISSN
15322327
07328303
07328303
Other identifier(s)
2-s2.0-45949089731
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Carbohydrate Chemistry. Vol.27, No.1 (2008), 32-40
Suggested Citation
Narayanan Parthasarathy, David DeShazer, Sharon J. Peacock, Vanaporn Wuthiekanun, Marilyn J. England, Sarah L. Norris, David M. Waag Application of polysaccharide microarray technology for the serodiagnosis of Burkholderia pseudomallei infection (melioidosis) in humans. Journal of Carbohydrate Chemistry. Vol.27, No.1 (2008), 32-40. doi:10.1080/07328300802030761 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18998
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Application of polysaccharide microarray technology for the serodiagnosis of Burkholderia pseudomallei infection (melioidosis) in humans
Other Contributor(s)
Abstract
Burkholderia pseudomallei is the causative agent of melioidosis, a bacterial infection endemic in tropical regions including southeast Asia and northern Australia. B. pseudomallei contains structurally unique polysaccharides (capsular polysaccharide and O-antigen saccharides of lipopolysaccharide). A polysaccharide microarray platform was developed by immobilizing these polysaccharides onto glass slides. Employing this microarray, we were able to demonstrate the presence of antibodies to these polysaccharide antigens in the sera of melioidosis patients, but not in serum from nonmelioidosis human subjects. The advantages of this polysaccharide microarray technology over the conventional tests for the serodiagnosis of melioidosis are discussed. Copyright © Taylor & Francis Group, LLC.