Publication:
Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF<inf>3</inf>

5

Issued Date

2021-10-01

Resource Type

Article

ISSN

00221139

DOI

10.1016/j.jfluchem.2021.109878

Other identifier(s)

2-s2.0-85114303231

Rights

Mahidol University

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SCOPUS

Bibliographic Citation

Journal of Fluorine Chemistry. Vol.250, (2021)

Suggested Citation

Jongkonporn Phetcharawetch, Nolan M. Betterley, Vichai Reutrakul, Darunee Soorukram, Pawaret Leowanawat, Chutima Kuhakarn Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF<inf>3</inf>. Journal of Fluorine Chemistry. Vol.250, (2021). doi:10.1016/j.jfluchem.2021.109878 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76013

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Title

Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF<inf>3</inf>

Author(s)

Jongkonporn Phetcharawetch
 Nolan M. Betterley
 Vichai Reutrakul
 Darunee Soorukram
 Pawaret Leowanawat
 Chutima Kuhakarn

Other Contributor(s)

Mahidol University

Abstract

Direct and effective trifluoromethylthiolation of 2-alkynyl azidoarenes with silver(I) trifluoromethanethiolate (AgSCF3) has been developed for the construction of 3-((trifluoromethyl)thio)indoles. The trifluoromethylthiolation protocol is compatible with a broad substrate scope, providing a variety of 3-((trifluoromethyl)thio)indoles in moderate to good yields within one step, open-air, and short reaction time.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Environmental Science

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URI

https://repository.li.mahidol.ac.th/handle/123456789/76013

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Scopus 2021