The Southeast Asian journal of tropical medicine and public health. Vol.18, No.1 (1987), 52-55
Suggested Citation
S. Angsubhakorn, J. B. Moe, N. J. Marchette, N. E. Palumbo, S. Yoksan, N. Bhamarapravati Neurovirulence effects of dengue-2 viruses on the rhesus (Macaca mulatta) brain and spinal cord.. The Southeast Asian journal of tropical medicine and public health. Vol.18, No.1 (1987), 52-55. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15431
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Neurovirulence effects of dengue-2 viruses on the rhesus (Macaca mulatta) brain and spinal cord.
Vaccines prepared from attenuated virus can cause symptomatic viral infection of the central nervous system. In the present study, dengue-2 parental and its live attenuated viruses were tested by intrathalamic and intraspinal injections in rhesus monkeys. The dengue-2 viruses were found to be only very weakly neurovirulent when injected directly into the brain or spinal cord of rhesus monkeys.
