Publication:
Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

7

Issued Date

2020-10-01

Resource Type

Article

ISSN

17683254
02235234

DOI

10.1016/j.ejmech.2020.112653

Other identifier(s)

2-s2.0-85088007294

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

European Journal of Medicinal Chemistry. Vol.203, (2020)

Suggested Citation

Canan G. Nebigil, Christiane Moog, Stéphan Vagner, Nadia Benkirane-Jessel, Duncan R. Smith, Laurent Désaubry Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses. European Journal of Medicinal Chemistry. Vol.203, (2020). doi:10.1016/j.ejmech.2020.112653 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/57806

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Title

Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Author(s)

Canan G. Nebigil
 Christiane Moog
 Stéphan Vagner
 Nadia Benkirane-Jessel
 Duncan R. Smith
 Laurent Désaubry

Other Contributor(s)

Universite Paris-Saclay
 Université de Strasbourg
 Institut Curie
 Mahidol University
 Les Hôpitaux Universitaires de Strasbourg
 Inserm

Abstract

© 2020 Elsevier Masson SAS Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Keyword(s)

Chemistry
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/57806

Collections

Scopus 2020