Publication:
Method development for separation of active ingredients in cold medicines by micellar electrokinetic chromatography

4

Issued Date

2003-09-30

Resource Type

Article

ISSN

22180532
00368709

Other identifier(s)

2-s2.0-0141459731

Rights

Mahidol University

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SCOPUS

Bibliographic Citation

Scientia Pharmaceutica. Vol.71, No.3 (2003), 235-250

Suggested Citation

Leena Suntornsuk, Ongart Pipitharome, Prapin Wilairat Method development for separation of active ingredients in cold medicines by micellar electrokinetic chromatography. Scientia Pharmaceutica. Vol.71, No.3 (2003), 235-250. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21026

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Title

Method development for separation of active ingredients in cold medicines by micellar electrokinetic chromatography

Author(s)

Leena Suntornsuk
 Ongart Pipitharome
 Prapin Wilairat

Other Contributor(s)

Mahidol University

Abstract

Separation of nine commonly used active ingredients in cold medicines, were demonstrated by micellar electrokinetic chromatography. The ingredients included paracetamol, chlorpheniramine maleate, diphenhydramine hydrochloride, triprolidine hydrochloride phenylpropanolamine hydrochloride, dextromethorphan hydrobromide, loratadine, aspirin and caffeine. Effects of buffer concentrations, pH, organic modifiers and capillary length were investigated. The optimum conditions were achieved in 10 mM sodium dihydrogenphosphate-sodium tetraborate buffer, pH 9.0, containing 50 mM sodium dodecyl sulfate and 28% v/v acetonitrile using the effective length of 50 cm, the separating voltage of +15 kV and the capillary temperature of 30°C. Separation of all peaks was obtained within 28.4 min with a resolution of 1.2.

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

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https://repository.li.mahidol.ac.th/handle/123456789/21026

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Scopus 2001-2005