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Characterization based on the 56-Kda type-specific antigen gene of Orientia tsutsugamushi genotypes isolated from Leptotrombidium mites and the rodent host post-infection

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dc.contributor.authorRatree Takhampunyaen_US
dc.contributor.authorBousaraporn Tippayachaien_US
dc.contributor.authorSommai Promsathapornen_US
dc.contributor.authorSurachai Leepitakraten_US
dc.contributor.authorTaweesak Monkannaen_US
dc.contributor.authorAnthony L. Schusteren_US
dc.contributor.authorMelanie C. Melendrezen_US
dc.contributor.authorDaniel H. Parisen_US
dc.contributor.authorAllen L. Richardsen_US
dc.contributor.authorJason H. Richardsonen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherWalter Reed Army Institute of Researchen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNaval Medical Research Centeren_US
dc.date.accessioned2018-11-09T02:25:45Z
dc.date.available2018-11-09T02:25:45Z
dc.date.issued2014-01-01en_US
dc.description.abstractCharacterization of the 56-kDa type-specific antigen (TSA) genes of Orientia tsutsugamushi (OT) from three naturally infected, laboratory-reared mite colonies comprising three species (Leptotrombidium deliense [Ld], Leptotrombidium imphalum [Li], and Leptotrombidium chiangraiensis [Lc]) has revealed the presence of single and coexisting OT genotypes found in individual chiggers. The Karp genotype was found in all of the chiggers examined, whereas Gilliam and UT302 genotypes were only observed in combination with the Karp genotype. From analysis of these OT genotypes after transmission from chiggers to mice it was determined that with the Lc and Li mites, the OT genotype composition in the rodent spleens post-infection had not changed and therefore resembled that observed in the feeding chiggers. However, only the Karp genotype was found in rodents after feeding by Ld chiggers carrying Karp and Gilliam genotypes. The current findings reveal a complex association among the host, pathogen, and vector. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.en_US
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene. Vol.90, No.1 (2014), 139-146en_US
dc.identifier.doi10.4269/ajtmh.13-0393en_US
dc.identifier.issn00029637en_US
dc.identifier.other2-s2.0-84892718839en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/34070
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84892718839&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleCharacterization based on the 56-Kda type-specific antigen gene of Orientia tsutsugamushi genotypes isolated from Leptotrombidium mites and the rodent host post-infectionen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84892718839&origin=inwarden_US

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