Publication: Multidrug resistance in Clostridium perfringens isolated from diarrheal neonatal piglets in Thailand
Issued Date
2016-04-01
Resource Type
ISSN
10958274
10759964
10759964
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2-s2.0-84954310090
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Mahidol University
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SCOPUS
Bibliographic Citation
Anaerobe. Vol.38, (2016), 88-93
Suggested Citation
Bhinyada Ngamwongsatit, Wimonrat Tanomsridachchai, Orasa Suthienkul, Supanee Urairong, Wichian Navasakuljinda, Tavan Janvilisri Multidrug resistance in Clostridium perfringens isolated from diarrheal neonatal piglets in Thailand. Anaerobe. Vol.38, (2016), 88-93. doi:10.1016/j.anaerobe.2015.12.012 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/40840
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Title
Multidrug resistance in Clostridium perfringens isolated from diarrheal neonatal piglets in Thailand
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Abstract
© 2016 Elsevier Ltd. Clostridium perfringens causes diarrhea in neonatal piglets, thereby affecting commercial swine farming. The objective of this study was to determine the prevalence and characterize antimicrobial resistance in C. perfringens isolated from diarrheal neonatal piglets in Thailand. A total of 260 rectal swab samples were collected from 13 farms and were subjected to C. perfringens isolation. A total of 148 samples were PCR-positive for C. perfringens toxin genes, from which 122 were recovered. All isolates were cpb2-encoding C. perfringens type A and enterotoxin gene negative. Most of the isolates were susceptible to ampicillin, bacitracin, chlorotetracycline, doxycycline, and oxytetracycline with MIC50values ranging from 0.32 to 8 μg/ml. The high resistance rates were observed for ceftiofur, enrofloxacin, erythromycin, lincomycin, and tylosin. Among resistant isolates, 82% were resistant to more than one type of antibiotics. The distinct pattern of multiple drug resistance in C. perfringens was observed in different regions, potentially reflecting the farm specific usage of these agents.