Publication: Impact of anca-associated vasculitis on outcomes of hospitalizations for goodpasture’s syndrome in the united states: Nationwide inpatient sample 2003–2014
Issued Date
2020-03-01
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1010660X
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2-s2.0-85080973535
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Mahidol University
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SCOPUS
Bibliographic Citation
Medicina (Lithuania). Vol.56, No.3 (2020)
Suggested Citation
Charat Thongprayoon, Wisit Kaewput, Boonphiphop Boonpheng, Patompong Ungprasert, Tarun Bathini, Narat Srivali, Saraschandra Vallabhajosyula, Jorge L. Castaneda, Divya Monga, Swetha R. Kanduri, Juan Medaura, Wisit Cheungpasitporn Impact of anca-associated vasculitis on outcomes of hospitalizations for goodpasture’s syndrome in the united states: Nationwide inpatient sample 2003–2014. Medicina (Lithuania). Vol.56, No.3 (2020). doi:10.3390/medicina56030103 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/53741
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Title
Impact of anca-associated vasculitis on outcomes of hospitalizations for goodpasture’s syndrome in the united states: Nationwide inpatient sample 2003–2014
Abstract
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background and objectives: Goodpasture’s syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture’s syndrome has been recognized, the impacts of ANCA vasculitis on mortality and resource utilization among patients with GS are unclear. Materials and Methods: We used the National Inpatient Sample to identify hospitalized patients with a principal diagnosis of GS from 2003 to 2014 in the database. The predictor of interest was the presence of ANCA-associated vasculitis. We tested the differences concerning in-hospital treatment and outcomes between GS patients with and without ANCA-associated vasculitis using logistic regression analysis with adjustment for other clinical characteristics. Results: A total of 964 patients were primarily admitted to hospital for GS. Of these, 84 (8.7%) had a concurrent diagnosis of ANCA-associated vasculitis. Hemoptysis was more prevalent in GS patients with ANCA-associated vasculitis. During hospitalization, GS patients with ANCA-associated required non-significantly more mechanical ventilation and non-invasive ventilation support, but non-significantly less renal replacement therapy and plasmapheresis than those with GS alone. There was no significant difference in in-hospital outcomes, including organ failure and mortality, between GS patients with and without ANCA-associated vasculitis. Conclusions: Our study demonstrated no significant differences between resource utilization and in-hospital mortality among hospitalized patients with coexistence of ANCA vasculitis and GS, compared to those with GS alone.