Publication: Genetic diversity and evolution of enterovirus A71 subgenogroup C1 from children with hand, foot, and mouth disease in Thailand
Issued Date
2021-08-01
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ISSN
14328798
03048608
03048608
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2-s2.0-85107140826
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Virology. Vol.166, No.8 (2021), 2209-2216
Suggested Citation
Jiratchaya Puenpa, Kamol Suwannakarn, Jira Chansaenroj, Chompoonut Auphimai, Nasamon Wanlapakorn, Sompong Vongpunsawad, Yong Poovorawan Genetic diversity and evolution of enterovirus A71 subgenogroup C1 from children with hand, foot, and mouth disease in Thailand. Archives of Virology. Vol.166, No.8 (2021), 2209-2216. doi:10.1007/s00705-021-05130-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77250
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Title
Genetic diversity and evolution of enterovirus A71 subgenogroup C1 from children with hand, foot, and mouth disease in Thailand
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Abstract
Enterovirus A71 (EV-A71) can cause hand, foot, and mouth disease (HFMD) in children and may be associated with severe neurological complications. There have been numerous reports of increased incidence of EV-A71 subgenogroup C1 (EV-A71 C1) infections associated with neurological diseases since the first occurrence in Germany in 2015. Here, we describe 11 full-length genome sequences of 2019 EV-A71 C1 strains isolated from HFMD patients in Thailand from 2019 to early 2020. The genetic evolution of 2019 EV-A71 C1 was traced in the outbreaks, and the emergence of multiple lineages was detected. Our results demonstrated that 2019 EV-A71 C1 from Thailand emerged through recombination between its nonstructural protein gene and those of other EV-A genotypes. Bayesian-based phylogenetic analysis showed that the 2019 EV-A71 C1 Thai strains share a common ancestor with variants in Europe (Denmark and France). The substitution rate for the 2019 EV-A71 C1 genome was estimated to be 4.38 × 10−3 substitutions/(site∙year−1) (95% highest posterior density interval: 3.84–4.94 × 10−3 substitutions/[site∙year−1]), approximating that observed between previous EV-A71 C1 outbreaks. These data are essential for understanding the evolution of EV-A C1 during the ongoing HFMD outbreak and may be relevant to disease outcomes in children worldwide.