Publication: New compounds, nanaomycin F and G, discovered by physicochemical screening from a culture broth of Streptomyces rosa subsp. notoensis OS-3966
Issued Date
2015-11-01
Resource Type
ISSN
13474421
13891723
13891723
Other identifier(s)
2-s2.0-84943352884
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Bioscience and Bioengineering. Vol.120, No.5 (2015), 596-600
Suggested Citation
Takuji Nakashima, Panitch Boonsnongcheep, Toru Kimura, Masato Iwatsuki, Noriko Sato, Kenichi Nonaka, Sompop Prathanturarug, Yoko Takahashi, Satoshi Omura New compounds, nanaomycin F and G, discovered by physicochemical screening from a culture broth of Streptomyces rosa subsp. notoensis OS-3966. Journal of Bioscience and Bioengineering. Vol.120, No.5 (2015), 596-600. doi:10.1016/j.jbiosc.2015.03.018 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35350
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
New compounds, nanaomycin F and G, discovered by physicochemical screening from a culture broth of Streptomyces rosa subsp. notoensis OS-3966
Other Contributor(s)
Abstract
© 2015 The Society for Biotechnology, Japan. Two new compounds, nanaomycin F and G, were isolated by physicochemical screening method from cultured broth of Streptomyces rosa subsp. notoensis OS-3966, which is known to produce nanaomycin A, B, C, D, and E. Nanaomycin F is a new nanaomycin analog, a 4a-hydroxyl analog of nanaomycin B. Nanaomycin G has a unique skeleton with 1-indanone infused with a tetrahydropyran ring. Nanaomycin A possesses broad antimicrobial activity but nanaomycin F and G demonstrated no bioactivity against all bacteria and fungi tested in this study. In addition, in both nanaomycin F and G, the production of superoxide radicals was majorly decreased in comparison to nanaomycin A. It was considered that the antimicrobial properties were lost as a result of the decrease in production of the superoxide radicals.