Publication: Characterization and utilization of acid-modified cross-linked Tapioca starch in pharmaceutical tablets
Issued Date
2003-08-15
Resource Type
ISSN
01448617
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2-s2.0-0038719810
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Mahidol University
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SCOPUS
Bibliographic Citation
Carbohydrate Polymers. Vol.53, No.3 (2003), 263-270
Suggested Citation
Napaporn Atichokudomchai, Saiyavit Varavinit Characterization and utilization of acid-modified cross-linked Tapioca starch in pharmaceutical tablets. Carbohydrate Polymers. Vol.53, No.3 (2003), 263-270. doi:10.1016/S0144-8617(03)00070-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20810
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Title
Characterization and utilization of acid-modified cross-linked Tapioca starch in pharmaceutical tablets
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Abstract
Tapioca starch was cross-linked in the presence of alkaline sodium trimetaphosphate solution. The cross-linked tapioca starch was hydrolyzed by 6% (w/v) HCl solution at room temperature for 192 h. The final product was dried by centrifugal spray dryer to obtain agglomerated acid-modified cross-linked tapioca starch. Spray-dried native tapioca starch, cross-linked tapioca starch and acid-modified tapioca starch were also studied parallel with that of acid-modified cross-linked tapioca starch. It was found that cross-linking didn't increase the relative crystallinity or the melting enthalpy of tapioca starch. Compression of both native and cross-linked tapioca starches gave tablets with a very low crushing strength. Acid hydrolysis introduced to remove the amorphous regions in order to increase the crystallinity of both types of starches, resulting in tablets with a higher crushing strength. In this respect tablets prepared from acid-modified cross-linked tapioca starch were better than those prepared from acid-modified tapioca starch. © 2003 Elsevier Science Ltd. All rights reserved.