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Serological and molecular analysis of HLA class I and II alleles in Thai patients with psoriasis vulgaris

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dc.contributor.authorS. Vejbaesyaen_US
dc.contributor.authorT. H. Eiermannen_US
dc.contributor.authorP. Suthipinititharmen_US
dc.contributor.authorC. Banchaen_US
dc.contributor.authorH. A.F. Stephensen_US
dc.contributor.authorK. Luangtrakoolen_US
dc.contributor.authorD. Chandanayingyongen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversitatsklinikum Hamburg-Eppendorf und Medizinische Fakultaten_US
dc.date.accessioned2018-07-04T08:04:46Z
dc.date.available2018-07-04T08:04:46Z
dc.date.issued1998-01-01en_US
dc.description.abstractThe HLA class I and class II alleles in 67 patients with type I psoriasis vulgaris, 23 patients with type II psoriasis vulgaris and 140 healthy individuals were analyzed. The frequencies of HLA-A2, -B46, -B57 and DQB1*0303 were significantly increased in type I psoriasis compared to the controls (Pc < 0.05). Molecular analysis of HLA-A2 alleles showed an increase in HLA-A*0207 and a decrease in HLA-A*0203 in type I psoriasis. HLA-DQB1*0301 was significantly decreased in type I psoriasis compared to the normal controls (Pc < 0.05). No association of any alleles with type II psoriasis was observed. This data demonstrated two susceptible haplotypes: HLA-A1-B57-DRB1*0701-DQA1*0201-DQB1*0303 (AH57.1) and HLA-A2-B46-DRB1 *0901-DQA1*0301-DQB1*0303 (AH46.1) for type I psoriasis in the Thai population. Besides, the haplotype AH46.1 was also associated with type II psoriasis.en_US
dc.identifier.citationTissue Antigens. Vol.52, No.4 (1998), 389-392en_US
dc.identifier.doi10.1111/j.1399-0039.1998.tb03061.xen_US
dc.identifier.issn00012815en_US
dc.identifier.other2-s2.0-0031696149en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/18329
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031696149&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleSerological and molecular analysis of HLA class I and II alleles in Thai patients with psoriasis vulgarisen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031696149&origin=inwarden_US

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