Publication: Physiologic uterine inflammation and labor onset: Integration of endocrine and mechanical signals
Issued Date
2013-02-01
Resource Type
ISSN
19337205
19337191
19337191
Other identifier(s)
2-s2.0-84870882491
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Reproductive Sciences. Vol.20, No.2 (2013), 154-167
Suggested Citation
Oksana Shynlova, Yu Hui Lee, Khetsopon Srikhajon, Stephen J. Lye Physiologic uterine inflammation and labor onset: Integration of endocrine and mechanical signals. Reproductive Sciences. Vol.20, No.2 (2013), 154-167. doi:10.1177/1933719112446084 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32542
Research Projects
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Title
Physiologic uterine inflammation and labor onset: Integration of endocrine and mechanical signals
Abstract
The mechanisms underlying the preparation of the uterus for labor are not fully understood. Our previous studies have shown that during pregnancy, the uterine muscle (myometrium) undergoes dramatic phenotypic modulation culminating in term labor. The current review will discuss the cellular mechanisms involved in the regulation of myometrial activity and its modulation by endocrine signals and by mechanical stimulation of the uterus by the growing fetus. In particular, the contribution of uterine inflammation to the onset of labor will be described. We provide evidence that increased production of cytokines/chemokines in pregnant myometrium is associated with uterine occupancy and regulated by progesterone, suggesting the integration of mechanical and endocrine signals. Myometrial cells can actively participate in the inflammatory process in the uterus through the release of multiple proinflammatory cytokines and chemokines, providing a strong signal for activation of immune cells, their subsequent infiltration into pregnant uterus, and the initiation of labor. © 2013 The Author(s).