Publication:
Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain

Issued Date

2003-01-01

Resource Type

Article

ISSN

13657852

DOI

10.1038/sj.pcan.4500663

Other identifier(s)

2-s2.0-0141613922

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Prostate Cancer and Prostatic Diseases. Vol.6, No.3 (2003), 212-216

Suggested Citation

R. Tohtong, K. Phattarasakul, A. Jiraviriyakul, T. Sutthiphongchai Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain. Prostate Cancer and Prostatic Diseases. Vol.6, No.3 (2003), 212-216. doi:10.1038/sj.pcan.4500663 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20776

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Title

Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain

Author(s)

R. Tohtong
 K. Phattarasakul
 A. Jiraviriyakul
 T. Sutthiphongchai

Other Contributor(s)

Mahidol University

Abstract

The role of myosin phosphorylation by myosin light chain kinase (MLCK) in regulating the invasiveness of metastatic cancer cells was investigated using the Dunning rat prostatic adenocarcinoma cell line, Mat Ly Lu, and in vitro invasion assay. Treatment with MLCK inhibitors resulted in marked reduction of invasiveness, which was principally due to impaired cellular motility, whereas the ability to survive and proliferate, to adhere to matrix, and to secrete gelatinases were minimally affected. © 2003 Nature Publishing Group.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/20776

Collections

Scopus 2001-2005