Publication: The abbreviated 2-1-1 schedule of purified chick embryo cell rabies vaccination for rabies postexposure treatment
3
Issued Date
1993-12-01
Resource Type
ISSN
00383619
Other identifier(s)
2-s2.0-0027764288
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.24, No.3 (1993), 461-466
Suggested Citation
C. Wasi, P. Chaiprasithikul, P. Auewarakul, P. Puthavathana, P. Thongcharoen, M. Trishnananda The abbreviated 2-1-1 schedule of purified chick embryo cell rabies vaccination for rabies postexposure treatment. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.24, No.3 (1993), 461-466. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22621
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Title
The abbreviated 2-1-1 schedule of purified chick embryo cell rabies vaccination for rabies postexposure treatment
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Abstract
During August 1988 to January 1990, the immunogenicity and safety of purified chick embryo cell rabies vaccine (PCEC) given by the conventional and abbreviated regimens in 82 vaccinees moderately to severely exposed to laboratory proven rabid animals were studied. The 16 vaccinees received PCEC six doses as conventional schedule on days 0, 3, 7, 14, 28 and 90, the 11 vaccinees received six doses of PCEC plus human rabies immune globulin (HRIG) on day 0. The 29 vaccinees received an abbreviated schedule of PCEC as two doses on day 0, one dose each on days 7 and 21 and the 26 cases received PCEC abbreviated schedule plus HRIG on day 0. The kinetics of the neutralizing antibodies on days 0, 7, 14, 28, 56, 180 and 365 were studied for comparative purpose. All vaccinees had high antibody levels from day 14 which last longer than a year and were safe after one year follow up. The adverse reactions of the vaccine were mild and self-limited.