Publication:
The involvement of microglial cells in japanese encephalitis infections

1

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mb-ar-chutima-2012.pdf (1.17 MB)

Accepted Date

2012-07-12

Issued Date

2012

Resource Type

Review Article

Language

eng

DOI

10.1155/2012/890586

Rights

Mahidol University

Bibliographic Citation

Clinical and Developmental Immunology. 2012, ID 890586

Suggested Citation

Thananya Thongtan, Chutima Thepparit, Smith, Duncan R. The involvement of microglial cells in japanese encephalitis infections. Clinical and Developmental Immunology. 2012, ID 890586. doi:10.1155/2012/890586 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/1806

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Title

The involvement of microglial cells in japanese encephalitis infections

Author(s)

Thananya Thongtan
 Chutima Thepparit
 Smith, Duncan R.

Other Contributor(s)

Mahidol University. Faculty of Medicine. Department of Microbiology.
 Mahidol University. Institute of Molecular Biosciences. Molecular Pathology Laboratory
 Mahidol University. Center for Emerging and Neglected Infectious Diseases

Abstract

Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.

Keyword(s)

Involvement
 Microglial Cells
 Japanese
 Encephalitis
 Infections
 Open Access article

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URI

https://repository.li.mahidol.ac.th/handle/123456789/1806

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MB-Article