Publication: Identification and expression of white spot syndrome virus-encoded microRNAs in infected Penaeus monodon
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Issued Date
2019-03-30
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ISSN
00448486
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2-s2.0-85060188331
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Mahidol University
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SCOPUS
Bibliographic Citation
Aquaculture. Vol.503, (2019), 436-445
Suggested Citation
Thaneeya Nantapojd, Sakol Panyim, Chalermporn Ongvarrasopone Identification and expression of white spot syndrome virus-encoded microRNAs in infected Penaeus monodon. Aquaculture. Vol.503, (2019), 436-445. doi:10.1016/j.aquaculture.2019.01.023 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/49794
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Title
Identification and expression of white spot syndrome virus-encoded microRNAs in infected Penaeus monodon
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Abstract
© 2019 Elsevier B.V. White spot syndrome virus (WSSV) is the most devastating DNA virus that causes shrimp mortality worldwide. To better understand WSSV and Penaeus monodon interactions, WSSV-encoded microRNAs (wsv-miRs) were identified by small RNA cloning and next-generation sequencing. Ten wsv-miRs were identified and their expressions can be detected in WSSV-infected tissues only. These wsv-miRs and their flanking sequences can spontaneously form hairpin structure as predicted by Mfold. The expression profiles of 6 wsv-miRs increased dependent on time course of WSSV infection and slightly decreased after 48 hours WSSV challenge. The highest expression was wsv-miR-9 followed by miR-13 and -15. Computational prediction of the candidate targets of wsv-miRs revealed possible functions of wsv-miRs in the controlling of apoptosis, transcription and signaling. This finding provided insights into WSSV-host interaction.