Publication: Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy
Issued Date
2003-05-01
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ISSN
00359203
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2-s2.0-4444231687
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Mahidol University
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SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.97, No.3 (2003), 273-276
Suggested Citation
Mathieu Nacher, Rose McGready, Kasia Stepniewska, Thein Cho, Sornchai Looareesuwan, Nicholas J. White, François Nosten Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.97, No.3 (2003), 273-276. doi:10.1016/S0035-9203(03)90140-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20905
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Title
Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy
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Abstract
Nutritional deficiency and malaria are 2 major causes of anaemia during pregnancy in tropical areas. The relationship between anaemia, its treatment with iron and folate, and malaria was studied in a prospective cohort of 2112 pregnant Karen women on the north-western border of Thailand between 1993 and 1997. The development of Plasmodium vivax malaria was associated with a past mean haematocrit, > 30% (hazard ratio = 1.5, 95% CI 1.2-2, P = 0.001) and recent (≤ 30 d) iron and folate supplementation (hazard ratio = 1.7, 95% CI 1.1-2.6, P= 0.01). There were no associations with P. falciparum infections. Plasmodium vivax has a predilection for young erythrocytes, and these results suggest that pregnant women with larger numbers of circulating young red cells are at greater risk of developing P. vivax malaria. In P. vivax-endemic areas, systematic iron and folate supplementation confers both benefit and risk in pregnancy. © 2003 Royal Society of Tropical Medicine and Hygiene.