Association of Helicobacter pylori with the Risk of Hepatic Encephalopathy

dc.contributor.authorKarn Wijarnpreechaen_US
dc.contributor.authorSupavit Chesdachaien_US
dc.contributor.authorCharat Thongprayoonen_US
dc.contributor.authorVeeravich Jaruvongvanichen_US
dc.contributor.authorPatompong Ungpraserten_US
dc.contributor.authorWisit Cheungpasitpornen_US
dc.contributor.otherBassett Medical Centeren_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Hawaii at Manoaen_US
dc.contributor.otherMayo Clinicen_US
dc.contributor.otherUniversity of Mississippi Medical Centeren_US
dc.description.abstract© 2017, Springer Science+Business Media, LLC, part of Springer Nature. Background/Objectives: Hepatic encephalopathy is the common manifestation of decompensated cirrhosis. The association between Helicobacter pylori (H. pylori) infection and hepatic encephalopathy has been shown in many epidemiologic studies. This meta-analysis was conducted to summarize all available studies to estimate the association between H. pylori infection and hepatic encephalopathy. Methods: A comprehensive literature review was conducted using MEDLINE and EMBASE database through March 2017 to identify studies that reported the association between H. pylori infection and hepatic encephalopathy. Effect estimates from the individual study were extracted and combined using random-effect, generic inverse variance method of DerSimonian and Laird. Results: Of 15,233 studies, eleven studies (four cross-sectional, four case–control, and three cohort studies) met the eligibility criteria and were included in the meta-analysis. The pooled OR of hepatic encephalopathy in patients with H. pylori infection was 1.73 (95% CI 1.09–2.73) when compared with the patients without H. pylori infection. The association between H. pylori and hepatic encephalopathy was not statistically significant after the sensitivity analysis, excluding those using ELISA alone, with a pooled OR of 1.92 (95% CI 0.91–4.05, I2 = 62%). There was no publication bias of overall included studies assessed by the funnel plots and Egger’s regression asymmetry test. Conclusions: This study demonstrated a potential association between H. pylori infection and risk of hepatic encephalopathy. Future studies are required to assess the effect of chronicity of infection on the development of hepatic encephalopathy.en_US
dc.identifier.citationDigestive Diseases and Sciences. Vol.62, No.12 (2017), 3614-3621en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAssociation of Helicobacter pylori with the Risk of Hepatic Encephalopathyen_US