Publication: Synthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor
| dc.contributor.author | Jiraporn Ungwitayatorn | en_US |
| dc.contributor.author | Chanpen Wiwat | en_US |
| dc.contributor.author | Weerasak Samee | en_US |
| dc.contributor.author | Patcharawee Nunthanavanit | en_US |
| dc.contributor.author | Narumol Phosrithong | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Srinakharinwirot University | en_US |
| dc.contributor.other | Siam University | en_US |
| dc.date.accessioned | 2018-05-03T08:07:00Z | |
| dc.date.available | 2018-05-03T08:07:00Z | |
| dc.date.issued | 2011-08-24 | en_US |
| dc.description.abstract | Novel chromone derivatives with a benzopyran-4-one scaffold have been prepared by the one-pot cyclization reaction. The in vitro inhibitory activity of these new compounds towards HIV-1 protease have been evaluated using stop time HPLC method as the preliminary screening. The most potent compound, 7,8-dihydroxy-2-(3′-trifluoromethyl phenyl)-3-(3″- trifluoromethylbenzoyl)chromone (32), showed IC 50 = 0.34 μM. The molecular docking study supported results from experimental activity testing and also provided structure-activity relationship of this series. © 2011 Elsevier B.V. All rights reserved. | en_US |
| dc.identifier.citation | Journal of Molecular Structure. Vol.1001, No.1-3 (2011), 152-161 | en_US |
| dc.identifier.doi | 10.1016/j.molstruc.2011.06.035 | en_US |
| dc.identifier.issn | 00222860 | en_US |
| dc.identifier.other | 2-s2.0-79961032360 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/11702 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79961032360&origin=inward | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | Synthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79961032360&origin=inward | en_US |