Publication:
Effects of point spread function-based image reconstruction on neuroreceptor binding in positron emission tomography study with [<sup>11</sup>C]FLB 457

dc.contributor.authorThonnapong Thongpraparnen_US
dc.contributor.authorYoko Ikomaen_US
dc.contributor.authorTakahiro Shiraishien_US
dc.contributor.authorTaiga Yamayaen_US
dc.contributor.authorHiroshi Itoen_US
dc.contributor.otherNational Institute of Radiological Sciences Chibaen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-12-11T02:55:51Z
dc.date.accessioned2019-03-14T08:01:38Z
dc.date.available2018-12-11T02:55:51Z
dc.date.available2019-03-14T08:01:38Z
dc.date.issued2016-01-01en_US
dc.description.abstract© 2015, Japanese Society of Radiological Technology and Japan Society of Medical Physics. The ordered subset expectation maximization with a point spread function (OSEM-PSF) was developed to improve the spatial resolution of reconstructed positron emission tomography (PET) images and has been reported to improve the contrast of hot spots in PET studies for oncology. However, in neuroreceptor imaging, the regional radioactivity concentration changes dynamically during the scan, and the effects of the PSF may differ among various radioligands or quantification methods. In this study, we investigated the effects of the PSF on quantification in PET studies with [11C]FLB 457 of dopamine D2receptors, using both phantom and human data acquired by the Siemens Biograph 16 imaging platform. In the phantom studies, we evaluated the hot contrast recovery coefficient (HCRC) for variously sized hot spheres and the linearity between the measured and true radioactivities in OSEM-PSF images. Next, in the human studies with [11C]FLB 457, radioactivity concentrations and binding potentials for the cerebral cortex and thalamus were compared between images reconstructed with and without PSF. In the phantom studies, the OSEM-PSF images showed a better HCRC compared to images without PSF, and they showed a good linear correlation with true radioactivity. In the human studies, the radioactivity concentration increased especially in small regions with high accumulation of [11C]FLB 457 when the PSF was included. However, little difference in the binding potentials was observed for the target regions between both types of reconstructed images. In conclusion, PSF-based reconstruction reduced the spill-over phenomena in small hot regions; however, it caused no increase in the binding potentials in the [11C]FLB 457 studies.en_US
dc.identifier.citationRadiological Physics and Technology. Vol.9, No.1 (2016), 127-137en_US
dc.identifier.doi10.1007/s12194-015-0343-0en_US
dc.identifier.issn18650341en_US
dc.identifier.issn18650333en_US
dc.identifier.other2-s2.0-84955628783en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/40730
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84955628783&origin=inwarden_US
dc.subjectHealth Professionsen_US
dc.titleEffects of point spread function-based image reconstruction on neuroreceptor binding in positron emission tomography study with [<sup>11</sup>C]FLB 457en_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84955628783&origin=inwarden_US

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