Publication:
Combined oral contraceptives and liver cancer

Issued Date

1989-01-01

Resource Type

Article

ISSN

10970215
00207136

DOI

10.1002/ijc.2910430215

Other identifier(s)

2-s2.0-0024516673

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

International Journal of Cancer. Vol.43, No.2 (1989), 254-259

Suggested Citation

Ramiro Molina, Luis Martinez, Oriana Salas, Aifredo Dabancens, Tao Yun, Chen Zhi‐Heng, Hu Yong‐Wei, Alvaro Cuadros, Nubia Aristizabal, Baruch Modan, Elaine Ron, Esther Alfandary, J. G. Mati, Patrick Kenya, Alfred Kungu, D. Gatei, Patrick A. Ibeziako, A. A. Abioye, T. A. Junaid, Patrick U. Aghadiuno, Ruben A. Apelo, Julietta R. De LaCruz, Jose Baens, Benjamin D. Canlas, Suporn Silpisornkosol, Tieng Pardthaisong, Boonlong Sivasomboom, Choti Theetranont, Banpot Boosiri, Supawat Chutivongse, Pramuan Virutamasen, Chansuda Wongsrichanalai, Sermsri Sindhvananda, Suporn Koetsawang, Duangdao Rachawat, Orawan Kiriwat, Nivat Chantarakul, P. P. Anthony, David B. Thomas, Janet L. Stanford, Roberta M. Ray, Elizabeth A. Noonan, Susan Holck Combined oral contraceptives and liver cancer. International Journal of Cancer. Vol.43, No.2 (1989), 254-259. doi:10.1002/ijc.2910430215 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15733

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Title

Combined oral contraceptives and liver cancer

Author(s)

Ramiro Molina
 Luis Martinez
 Oriana Salas
 Aifredo Dabancens
 Tao Yun
 Chen Zhi‐Heng
 Hu Yong‐Wei
 Alvaro Cuadros
 Nubia Aristizabal
 Baruch Modan
 Elaine Ron
 Esther Alfandary
 J. G. Mati
 Patrick Kenya
 Alfred Kungu
 D. Gatei
 Patrick A. Ibeziako
 A. A. Abioye
 T. A. Junaid
 Patrick U. Aghadiuno
 Ruben A. Apelo
 Julietta R. De LaCruz
 Jose Baens
 Benjamin D. Canlas
 Suporn Silpisornkosol
 Tieng Pardthaisong
 Boonlong Sivasomboom
 Choti Theetranont
 Banpot Boosiri
 Supawat Chutivongse
 Pramuan Virutamasen
 Chansuda Wongsrichanalai
 Sermsri Sindhvananda
 Suporn Koetsawang
 Duangdao Rachawat
 Orawan Kiriwat
 Nivat Chantarakul
 P. P. Anthony
 David B. Thomas
 Janet L. Stanford
 Roberta M. Ray
 Elizabeth A. Noonan
 Susan Holck

Other Contributor(s)

Facultad de Medicina de la Universidad de Chile
 Shanghai Institute of Planned Parenthood Research
 Hospital Universitario
 Chaim Sheba Medical Center Israel
 University of Nairobi
 University of Ibadan
 University of the Philippines Manila
 Chiang Mai University
 Chulalongkorn University
 Mahidol University
 Exeter North Devon Health Authority
 Fred Hutchinson Cancer Research Center
 Organisation Mondiale de la Sante

Abstract

A multi‐national, hospital‐based, case‐control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever used combined oral contraceptives was estimated to be 0.71 (95% Cl 0.4–1.2). No consistent trend in risk with months of use or time since first or last use was observed. Separate analyses also revealed no association between use of combined oral contraceptives and hepatocellular carcinoma (RR = 0.60) or cholangiocarcinoma (RR = 1.22). Most women in this study came from areas in which hepatitis B is endemic and rates of liver cancer are relatively high, and in most cases use of oral contraceptives was of short duration. These results provide no evidence that short‐term use of oral contraceptives enhances risk of liver cancer in countries where the determinants of this disease are similar to those observed in the countries where this study was conducted. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/15733

Collections

Scopus 1969-1990