Publication: Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies
dc.contributor.author | Rupam Tripura | en_US |
dc.contributor.author | Peto, Thomas J. | en_US |
dc.contributor.author | Jeremy Chalk | en_US |
dc.contributor.author | Lee, Sue J. | en_US |
dc.contributor.author | Pasathorn Sirithiranont | en_US |
dc.contributor.author | Chea Nguon | en_US |
dc.contributor.author | Mehul Dhorda | en_US |
dc.contributor.author | Seidlein, Lorenz von | en_US |
dc.contributor.author | Maude, Richard J. | en_US |
dc.contributor.author | Day, Nicholas P. J. | en_US |
dc.contributor.author | Mallika Imwong | en_US |
dc.contributor.author | White, Nicholas J. | en_US |
dc.contributor.author | Dondorp, Arjen M. | en_US |
dc.contributor.other | Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit | en_US |
dc.date.accessioned | 2017-11-15T14:44:26Z | |
dc.date.available | 2017-11-15T14:44:26Z | |
dc.date.created | 2017-11-15 | |
dc.date.issued | 2016 | |
dc.description.abstract | Background: Subclinical Plasmodium parasitaemia is an important reservoir for the transmission and persistence of malaria, particularly in low transmission areas. Methods: Using ultrasensitive quantitative PCR (uPCR) for the detection of parasitaemia, the entire population of three Cambodian villages in Pailin province were followed for 1 year at three-monthly intervals. A cohort of adult participants found initially to have asymptomatic malaria parasitaemia was followed monthly over the same period. Results: The initial cross sectional survey in June 2013 (M0) of 1447 asymptomatic residents found that 32 (2.2 %) had Plasmodium falciparum, 48 (3.3 %) had P. vivax, 4 (0.3 %) had mixed infections and in 142/1447 (9.8 %) malaria was detected but there was insufficient DNA to identify the species (Plasmodium. species). Polymorphisms in the ‘K13-propeller’ associated with reduced susceptibility to artemisinin derivatives (C580Y) were found in 17/32 (51 %) P. falciparum strains. Monthly follow-up without treatment of 24 adult participants with asymptomatic mono or mixed P. falciparum infections found that 3/24 (13 %) remained parasitaemic for 2–4 months, whereas the remaining 21/24 (87 %) participants had cleared their parasitaemia after 1 month. In contrast, 12/34 (35 %) adult participants with P. vivax mono-infection at M0 had malaria parasites (P. vivax or P. sp.) during four or more of the following 11 monthly surveys. Conclusions: This longitudinal survey in a low transmission setting shows limited duration of P. falciparum carriage, but prolonged carriage of P. vivax infections. Radical treatment of P. vivax infections by 8-aminoquinoline regimens may be required to eliminate all malaria from Cambodia. Trial registration ClinicalTrials.gov NCT01872702 | en_US |
dc.identifier.citation | Malaria Journal. Vol.15, (2016), 181 | en_US |
dc.identifier.doi | 10.1186/s12936-016-1224-7 | |
dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/3149 | |
dc.language.iso | eng | en_US |
dc.rights | Mahidol University | en_US |
dc.rights.holder | BioMed Central | en_US |
dc.subject | Open Access article | en_US |
dc.subject | Malaria | en_US |
dc.subject | Persistence | en_US |
dc.subject | Cohort | en_US |
dc.subject | Plasmodium | en_US |
dc.subject | Falciparum | en_US |
dc.subject | Vivax | en_US |
dc.subject | Clearance | en_US |
dc.subject | Artemisinins | en_US |
dc.subject | Resistance | en_US |
dc.subject | Pailin | en_US |
dc.subject | Cambodia | en_US |
dc.subject | PCR | en_US |
dc.title | Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies | en_US |
dc.type | Research Article | en_US |
dspace.entity.type | Publication |