Publication: Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells
Issued Date
2021-08-01
Resource Type
ISSN
20585276
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2-s2.0-85111121161
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Microbiology. Vol.6, No.8 (2021), 991-999
Suggested Citation
Benoît Malleret, Abbas El Sahili, Matthew Zirui Tay, Guillaume Carissimo, Alice Soh Meoy Ong, Wisna Novera, Jianqing Lin, Rossarin Suwanarusk, Varakorn Kosaisavee, Trang T.T. Chu, Ameya Sinha, Shanshan Wu Howland, Yiping Fan, Jakub Gruszczyk, Wai Hong Tham, Yves Colin, Sebastian Maurer-Stroh, Georges Snounou, Lisa F.P. Ng, Jerry Kok Yen Chan, Ann Marie Chacko, Julien Lescar, Rajesh Chandramohanadas, François Nosten, Bruce Russell, Laurent Rénia Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells. Nature Microbiology. Vol.6, No.8 (2021), 991-999. doi:10.1038/s41564-021-00939-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76090
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Title
Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells
Author(s)
Benoît Malleret
Abbas El Sahili
Matthew Zirui Tay
Guillaume Carissimo
Alice Soh Meoy Ong
Wisna Novera
Jianqing Lin
Rossarin Suwanarusk
Varakorn Kosaisavee
Trang T.T. Chu
Ameya Sinha
Shanshan Wu Howland
Yiping Fan
Jakub Gruszczyk
Wai Hong Tham
Yves Colin
Sebastian Maurer-Stroh
Georges Snounou
Lisa F.P. Ng
Jerry Kok Yen Chan
Ann Marie Chacko
Julien Lescar
Rajesh Chandramohanadas
François Nosten
Bruce Russell
Laurent Rénia
Abbas El Sahili
Matthew Zirui Tay
Guillaume Carissimo
Alice Soh Meoy Ong
Wisna Novera
Jianqing Lin
Rossarin Suwanarusk
Varakorn Kosaisavee
Trang T.T. Chu
Ameya Sinha
Shanshan Wu Howland
Yiping Fan
Jakub Gruszczyk
Wai Hong Tham
Yves Colin
Sebastian Maurer-Stroh
Georges Snounou
Lisa F.P. Ng
Jerry Kok Yen Chan
Ann Marie Chacko
Julien Lescar
Rajesh Chandramohanadas
François Nosten
Bruce Russell
Laurent Rénia
Other Contributor(s)
A-Star, Infectious Disease Lab
Faculty of Tropical Medicine, Mahidol University
Université Paris Cité
NTU Institute of Structural Biology
A-Star, Singapore Immunology Network
Singapore University of Technology and Design
School of Biological Sciences
Duke-NUS Medical School
Walter and Eliza Hall Institute of Medical Research
NUS Yong Loo Lin School of Medicine
University of Melbourne
A-Star, Bioinformatics Institute
University of Otago
National University of Singapore
Institut National de la Transfusion Sanguine
KK Women's And Children's Hospital
Mahidol University
CEA Fontenay aux Roses
Nuffield Department of Medicine
Nanyang Technological University
Faculty of Tropical Medicine, Mahidol University
Université Paris Cité
NTU Institute of Structural Biology
A-Star, Singapore Immunology Network
Singapore University of Technology and Design
School of Biological Sciences
Duke-NUS Medical School
Walter and Eliza Hall Institute of Medical Research
NUS Yong Loo Lin School of Medicine
University of Melbourne
A-Star, Bioinformatics Institute
University of Otago
National University of Singapore
Institut National de la Transfusion Sanguine
KK Women's And Children's Hospital
Mahidol University
CEA Fontenay aux Roses
Nuffield Department of Medicine
Nanyang Technological University
Abstract
More than one-third of the world’s population is exposed to Plasmodium vivax malaria, mainly in Asia1. P. vivax preferentially invades reticulocytes (immature red blood cells)2–4. Previous work has identified 11 parasite proteins involved in reticulocyte invasion, including erythrocyte binding protein 2 (ref. 5) and the reticulocyte-binding proteins (PvRBPs)6–10. PvRBP2b binds to the transferrin receptor CD71 (ref. 11), which is selectively expressed on immature reticulocytes12. Here, we identified CD98 heavy chain (CD98), a heteromeric amino acid transporter from the SLC3 family (also known as SLCA2), as a reticulocyte-specific receptor for the PvRBP2a parasite ligand using mass spectrometry, flow cytometry, biochemical and parasite invasion assays. We characterized the expression level of CD98 at the surface of immature reticulocytes (CD71+) and identified an interaction between CD98 and PvRBP2a expressed at the merozoite surface. Our results identify CD98 as an additional host membrane protein, besides CD71, that is directly associated with P. vivax reticulocyte tropism. These findings highlight the potential of using PvRBP2a as a vaccine target against P. vivax malaria.