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Protection against cancer through nutritionally-induced increase of endogenous proteinase inhibitors - a hypothesis

dc.contributor.authorFrank Peter Schelpen_US
dc.contributor.authorPraneet Pongpaewen_US
dc.contributor.otherInstitute for Social Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-06-14T09:09:12Z
dc.date.available2018-06-14T09:09:12Z
dc.date.issued1988-06-01en_US
dc.description.abstractPopulation groups with a diet low in calories, fat and animal protein, but high in vegetables and fibre, have a low incidence of cancer of the colon, rectum, breast and prostate. It is proposed that such a diet protects against cancer by stimulating an increase of endogenous proteinase inhibitors (PI), in particular, alpha 2 -macroglobulin (AM), above those of individuals on a diet rich in calories, fat and animal protein. Evidence in support of this hypothesis is discussed. In various models, PI has been shown to be anticarcinogenistic. Preschool and school children who although on a diet apparently below the requirements for protein and calories were still considered healthy, have been found to have increased AM levels. Raised PI levels have also been observed in rats low on protein and energy and restriction of food intake in an inbred colony of rats reduced the incidence of radiation-induced tumours. © 1988 International Epidemiological Association.en_US
dc.identifier.citationInternational Journal of Epidemiology. Vol.17, No.2 (1988), 287-292en_US
dc.identifier.doi10.1093/ije/17.2.287en_US
dc.identifier.issn03005771en_US
dc.identifier.other2-s2.0-0023801170en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/15622
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023801170&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleProtection against cancer through nutritionally-induced increase of endogenous proteinase inhibitors - a hypothesisen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023801170&origin=inwarden_US

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