Publication: Recent Studies on the Abnormal Hemoglobins found in Thailand
Issued Date
1999-12-01
Resource Type
ISSN
02535106
Other identifier(s)
2-s2.0-0033269154
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Chemical Society of Pakistan. Vol.21, No.3 (1999), 281-288
Suggested Citation
Jisnuson Svasti, Chantragan Srisomsap, Dalina Itchayanan, Aree Limwuttiwóng, Wipapun Siriboon, Pranee Winichagoon, Suthat Fucharoen Recent Studies on the Abnormal Hemoglobins found in Thailand. Journal of Chemical Society of Pakistan. Vol.21, No.3 (1999), 281-288. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25376
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Recent Studies on the Abnormal Hemoglobins found in Thailand
Other Contributor(s)
Abstract
Numerous abnormal hemoglobins (Hb) have been discovered in Thailand, and yet further studies continue to show additional variants not previously described. This paper reviews the discovery of two more variants, as well as additional studies on families with unusual combinations of mutations. One proposita had an abnormal Hb with similar electrophoretic mobility to Hb J Bangkok, but tryptic peptide mapping by h.p.l.c., amino acid analysis and protein sequence analysis revealed an abnormal peptide α-T9, due to the mutation [α61 Lys-Asn], previously found in Hungary and identified as Hb J Buda. Direct DNA sequence analysis confirmed this result, and showed that the mutation occurred in the α1 gene and not the α2-gene. The abnormal Hb in another proposita was shown by peptide mapping, protein sequence analysis, and DNA sequence analysis, to be identical to Hb G Coushatta [β22 Glu-Ala]. In addition to the above variants, unusual combinations of mutations from two other families were studied, namely the combination of Hb E (common in Thailand) with Hb C (common in African populations) and the combination of Hb E/β17-thalassemia/β41-42-thalassemia.