Publication:
Unpolished Thai rice prevents aberrant crypt foci formation through the invovement of β-catenin and COX-2 expression in azoxymethane-treated rats

dc.contributor.authorSareeya Reungpatthanaphongen_US
dc.contributor.authorChaiyavat Chaiyasuten_US
dc.contributor.authorSasithorn Sirilunen_US
dc.contributor.authorPrasit Suwannalerten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChiang Mai Universityen_US
dc.date.accessioned2018-12-11T02:22:27Z
dc.date.accessioned2019-03-14T08:04:14Z
dc.date.available2018-12-11T02:22:27Z
dc.date.available2019-03-14T08:04:14Z
dc.date.issued2016-01-01en_US
dc.description.abstractColorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world, with chronic inflammation and diet as major causes in its development. Chemopreventive effects of natural dietary products have been the focus of studies for prevention over the past decade. This study was conducted to determine the effects of unpolished Thai rice during precancerous stage through the involvement of β-catenin, cyclooxygenase-2 (COX-2) expression and inflammatory cytokines focusing on azoxymethane (AOM)-induced aberrant crypt foci (ACF)-related to CRC. Male Sprague Dawley rats received two injections of AOM (15 mg/kg body weight) at weeks 4 and 5 while rats were treated with 20% or 70% unpolished Thai rice. The rats were sacrificed at week 38 and the colons removed for aberrant crypt foci (ACF) identification. Histopathologic changes, immunohistochemical analysis of β-catenin and COX-2 expression, and cytokine expression of proinflammatory and anti-inflammatory markers were determined. The administration of unpolished Thai rice significantly and dose dependently decreased the total number of ACF and the percentages of ACF with high-grade dysplasia. Interestingly, unpolished Thai rice suppressed the expression of β-catenin and COX-2. In addition, it also altered proinflammatory (IL-6 and IFN-γ) and anti-inflammatory (IL- 10) markers. The results suggested that unpolished Thai rice may provide a promising dietary intake for prevention during precancerous stage of CRC development, through the involvement of β-catenin and COX-2 expression, and also modulate inflammatory cytokines-related to CRC.en_US
dc.identifier.citationAsian Pacific Journal of Cancer Prevention. Vol.17, No.7 (2016), 3551-3558en_US
dc.identifier.issn15137368en_US
dc.identifier.other2-s2.0-84983326108en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/43159
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84983326108&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleUnpolished Thai rice prevents aberrant crypt foci formation through the invovement of β-catenin and COX-2 expression in azoxymethane-treated ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84983326108&origin=inwarden_US

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