Publication:
Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter-and intracontinental transmission events

Issued Date

2015-05-27

Resource Type

Article

ISSN

15461718
10614036

DOI

10.1038/ng.3281

Other identifier(s)

2-s2.0-84930064392

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Nature Genetics. Vol.47, No.6 (2015), 632-639

Suggested Citation

Vanessa K. Wong, Stephen Baker, Derek J. Pickard, Julian Parkhill, Andrew J. Page, Nicholas A. Feasey, Robert A. Kingsley, Nicholas R. Thomson, Jacqueline A. Keane, François Xavier Weill, David J. Edwards, Jane Hawkey, Simon R. Harris, Alison E. Mather, Amy K. Cain, James Hadfield, Peter J. Hart, Nga Tran Vu Thieu, Elizabeth J. Klemm, Dafni A. Glinos, Robert F. Breiman, Conall H. Watson, Samuel Kariuki, Melita A. Gordon, Robert S. Heyderman, Chinyere Okoro, Jan Jacobs, Octavie Lunguya, W. John Edmunds, Chisomo Msefula, Jose A. Chabalgoity, Mike Kama, Kylie Jenkins, Shanta Dutta, Florian Marks, Josefina Campos, Corinne Thompson, Stephen Obaro, Calman A. Maclennan, Christiane Dolecek, Karen H. Keddy, Anthony M. Smith, Christopher M. Parry, Abhilasha Karkey, E. Kim Mulholland, James I. Campbell, Sabina Dongol, Buddha Basnyat, Muriel Dufour, Don Bandaranayake, Take Toleafoa Naseri, Shalini Pravin Singh, Mochammad Hatta, Paul Newton, Robert S. Onsare, Lupeoletalalei Isaia, David Dance, Viengmon Davong, Guy Thwaites, Lalith Wijedoru, John A. Crump, Elizabeth De Pinna, Satheesh Nair, Eric J. Nilles, Duy Pham Thanh, Paul Turner, Sona Soeng, Mary Valcanis, Joan Powling, Karolina Dimovski, Geoff Hogg, Jeremy Farrar, Kathryn E. Holt Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter-and intracontinental transmission events. Nature Genetics. Vol.47, No.6 (2015), 632-639. doi:10.1038/ng.3281 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35455

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Title

Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter-and intracontinental transmission events

Author(s)

Vanessa K. Wong
 Stephen Baker
 Derek J. Pickard
 Julian Parkhill
 Andrew J. Page
 Nicholas A. Feasey
 Robert A. Kingsley
 Nicholas R. Thomson
 Jacqueline A. Keane
 François Xavier Weill
 David J. Edwards
 Jane Hawkey
 Simon R. Harris
 Alison E. Mather
 Amy K. Cain
 James Hadfield
 Peter J. Hart
 Nga Tran Vu Thieu
 Elizabeth J. Klemm
 Dafni A. Glinos
 Robert F. Breiman
 Conall H. Watson
 Samuel Kariuki
 Melita A. Gordon
 Robert S. Heyderman
 Chinyere Okoro
 Jan Jacobs
 Octavie Lunguya
 W. John Edmunds
 Chisomo Msefula
 Jose A. Chabalgoity
 Mike Kama
 Kylie Jenkins
 Shanta Dutta
 Florian Marks
 Josefina Campos
 Corinne Thompson
 Stephen Obaro
 Calman A. Maclennan
 Christiane Dolecek
 Karen H. Keddy
 Anthony M. Smith
 Christopher M. Parry
 Abhilasha Karkey
 E. Kim Mulholland
 James I. Campbell
 Sabina Dongol
 Buddha Basnyat
 Muriel Dufour
 Don Bandaranayake
 Take Toleafoa Naseri
 Shalini Pravin Singh
 Mochammad Hatta
 Paul Newton
 Robert S. Onsare
 Lupeoletalalei Isaia
 David Dance
 Viengmon Davong
 Guy Thwaites
 Lalith Wijedoru
 John A. Crump
 Elizabeth De Pinna
 Satheesh Nair
 Eric J. Nilles
 Duy Pham Thanh
 Paul Turner
 Sona Soeng
 Mary Valcanis
 Joan Powling
 Karolina Dimovski
 Geoff Hogg
 Jeremy Farrar
 Kathryn E. Holt

Other Contributor(s)

Wellcome Trust Sanger Institute
 Addenbrooke's Hospital
 University of Oxford
 Nuffield Department of Clinical Medicine
 London School of Hygiene & Tropical Medicine
 Liverpool School of Tropical Medicine
 Quadram Institute Bioscience
 Institut Pasteur, Paris
 Bio21 Molecular Science and Biotechnology Institute
 University of Melbourne
 University of Birmingham
 Kenya Medical Research Institute
 Centers for Disease Control and Prevention
 Emory Global Health Institute
 University of Liverpool
 University of Malawi College of Medicine
 Prins Leopold Instituut voor Tropische Geneeskunde
 KU Leuven
 National Institute for Biomedical Research
 University Hospital of Kinshasa
 Universidad de la Republica Instituto de Higiene
 Ministry of Health
 Fiji Health Sector Support Program
 National Institute of Cholera and Enteric Diseases India
 International Vaccine Institute, Seoul
 Administracion Nacional de Laboratorios E Institutos de Salud Dr. Carlos G. Malbran
 University of Nebraska Medical Center
 University of Abuja
 Bingham University
 Novartis Vaccines Institute for Global Health
 University of Witwatersrand
 Nagasaki University
 Murdoch Children's Research Institute
 ESR - Environmental Science and Research
 Samoa Ministry of Health
 Organisation Mondiale de la Sante
 Hasanuddin University
 Mahosot Hospital
 Tupua Tamasese Meaole Hospital
 Mahidol University
 Chelsea and Westminster Hospital
 University of Otago
 Public Health England
 Angkor Hospital for Children

Abstract

© 2015 Nature America, Inc. All rights reserved. The emergence of multidrug-resistant (MDR) typhoid is a major global health threat affecting many countries where the disease is endemic. Here whole-genome sequence analysis of 1,832 Salmonella enterica serovar Typhi (S. Typhi) identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years. Our analysis identifies numerous transmissions of H58, including multiple transfers from Asia to Africa and an ongoing, unrecognized MDR epidemic within Africa itself. Notably, our analysis indicates that H58 lineages are displacing antibiotic-sensitive isolates, transforming the global population structure of this pathogen. H58 isolates can harbor a complex MDR element residing either on transmissible IncHI1 plasmids or within multiple chromosomal integration sites. We also identify new mutations that define the H58 lineage. This phylogeographical analysis provides a framework to facilitate global management of MDR typhoid and is applicable to similar MDR lineages emerging in other bacterial species.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/35455

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Scopus 2011-2015