Publication: Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria
Issued Date
2012-03-01
Resource Type
ISSN
15326535
00099236
00099236
Other identifier(s)
2-s2.0-84857233900
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Pharmacology and Therapeutics. Vol.91, No.3 (2012), 497-505
Suggested Citation
J. Tarning, I. Zongo, F. A. Somé, N. Rouamba, S. Parikh, P. J. Rosenthal, W. Hanpithakpong, N. Jongrak, N. P.J. Day, N. J. White, F. Nosten, J. B. Ouedraogo, N. Lindegardh Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria. Clinical Pharmacology and Therapeutics. Vol.91, No.3 (2012), 497-505. doi:10.1038/clpt.2011.254 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14942
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Title
Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria
Abstract
Dihydroartemisinin-piperaquine is being increasingly used as a first-line artemisinin combination treatment for malaria. The aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso. They received a standard body weight-based oral 3-day fixed-dose dihydroartemisinin- piperaquine regimen. Capillary plasma concentration-time profiles were characterized using nonlinear mixed-effects modeling. The population pharmacokinetics of piperaquine were described accurately by a two-transit-compartment absorption model and a three-compartment distribution model. Body weight was a significant covariate affecting clearance and volume parameters. The individually predicted day 7 capillary plasma concentration of piperaquine was an important predictor (P < 0.0001) of recurrent malaria infection after treatment. Young children (2-5 years of age) received a significantly higher body weight-normalized dose than older children (P = 0.025) but had significantly lower day 7 piperaquine concentrations (P = 0.024) and total piperaquine exposures (P = 0.021), suggesting that an increased dose regimen for young children should be evaluated. © 2012 american Society for clinical Pharmacology and Therapeutics.