Publication: Probiotics and amelioration of rheumatoid arthritis: Significant roles of lactobacillus casei and lactobacillus acidophilus
Issued Date
2021-05-01
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ISSN
20762607
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2-s2.0-85105700163
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Mahidol University
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SCOPUS
Bibliographic Citation
Microorganisms. Vol.9, No.5 (2021)
Suggested Citation
Alok K. Paul, Anita Paul, Rownak Jahan, Khoshnur Jannat, Tohmina A. Bondhon, Anamul Hasan, Veeranoot Nissapatorn, Maria L. Pereira, Polrat Wilairatana, Mohammed Rahmatullah Probiotics and amelioration of rheumatoid arthritis: Significant roles of lactobacillus casei and lactobacillus acidophilus. Microorganisms. Vol.9, No.5 (2021). doi:10.3390/microorganisms9051070 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77293
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Title
Probiotics and amelioration of rheumatoid arthritis: Significant roles of lactobacillus casei and lactobacillus acidophilus
Abstract
Rheumatoid arthritis is a chronic autoimmune disorder that can lead to disability conditions with swollen joints, pain, stiffness, cartilage degradation, and osteoporosis. Genetic, epigenetic, sex-specific factors, smoking, air pollution, food, oral hygiene, periodontitis, Prevotella, and imbalance in the gastrointestinal microbiota are possible sources of the initiation or progression of rheuma-toid arthritis, although the detailed mechanisms still need to be elucidated. Probiotics containing Lactobacillus spp. are commonly used as alleviating agents or food supplements to manage diarrhea, dysentery, develop immunity, and maintain general health. The mechanism of action of Lactobacillus spp. against rheumatoid arthritis is still not clearly known to date. In this narrative review, we reca-pitulate the findings of recent studies to understand the overall pathogenesis of rheumatoid arthritis and the roles of probiotics, particularly L. casei or L. acidophilus, in the management of rheumatoid arthritis in clinical and preclinical studies.