Publication:
Mutations of AML1 in non-MO acute myeloid leukemia: Six novel mutations and a high incidence of cooperative events in a South-east Asian population

Issued Date

2006-05-01

Resource Type

Article

ISSN

03906078

Other identifier(s)

2-s2.0-33744465781

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Haematologica. Vol.91, No.5 (2006), 675-678

Suggested Citation

Chirayu U. Auewarakul, Amporn Leecharendkeat, Wanna Thongnoppakhun, Chanin Limwongse, Chintana Tocharoentanaphol Mutations of AML1 in non-MO acute myeloid leukemia: Six novel mutations and a high incidence of cooperative events in a South-east Asian population. Haematologica. Vol.91, No.5 (2006), 675-678. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23750

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Title

Mutations of AML1 in non-MO acute myeloid leukemia: Six novel mutations and a high incidence of cooperative events in a South-east Asian population

Author(s)

Chirayu U. Auewarakul
 Amporn Leecharendkeat
 Wanna Thongnoppakhun
 Chanin Limwongse
 Chintana Tocharoentanaphol

Other Contributor(s)

Mahidol University

Abstract

Point mutations of AML1 are uncommon and predominantly reported in a rare minimally differentiated acute myeloid leukemia (MO AML). Few data exist regarding the frequency of AML1 mutations in non-MO cases. We screened 284 consecutive adult Thai patients with de novo AML and found that 3.9% had AML1 mutations. The highest incidence occurred in M6. Six novel mutations were uniquely identified in non-MO cases. Sixty-four percent of the non-MO patients with AML1 mutations had coexisting genetic abnormalities including FLT3 mutation in 36%. Our study provides evidence to support the model of multiple co-operating events, which could also be critical in the development of leukemia in non-MO AML patients with mutated AML1. The prognostic significance of these novel mutations remains to be determined. ©2006 Ferrata Storti Foundation.

Keyword(s)

Medicine

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https://repository.li.mahidol.ac.th/handle/20.500.14594/23750

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Scopus 2006-2010