Publication: Increased health risk in Bangkok children exposed to polycyclic aromatic hydrocarbons from traffic-related sources
Issued Date
2007-04-01
Resource Type
ISSN
14602180
01433334
01433334
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2-s2.0-34047137209
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Mahidol University
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SCOPUS
Bibliographic Citation
Carcinogenesis. Vol.28, No.4 (2007), 816-822
Suggested Citation
Jantamas Tuntawiroon, Chulabhorn Mahidol, Panida Navasumrit, Herman Autrup, Mathuros Ruchirawat Increased health risk in Bangkok children exposed to polycyclic aromatic hydrocarbons from traffic-related sources. Carcinogenesis. Vol.28, No.4 (2007), 816-822. doi:10.1093/carcin/bgl175 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24219
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Title
Increased health risk in Bangkok children exposed to polycyclic aromatic hydrocarbons from traffic-related sources
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Abstract
The aim of this study is to assess potential health risk of exposure to particle-associated polycyclic aromatic hydrocarbons (PAHs) in children living in a megacity with traffic congestion such as Bangkok. The study population comprised 184 Thai schoolboys (aged 8-13 years) attending schools adjacent to high-density traffic areas in Bangkok and schools located in the provincial area of Chonburi. The ambient concentration of total PAHs at roadsides in proximity to the Bangkok schools was 30-fold greater than at roadsides in proximity to the provincial schools (30.39 ± 5.80 versus 1.50 ± 0.28 ng/m 3; P < 0.001). Benzo(g,h,i)perylene (BghiP), an indicator of automobile exhaust emission, was the predominant PAH. Personal exposure to total PAHs and the corresponding benzo(a)pyrene (BaP) equivalent concentrations in Bangkok schoolchildren were 3.5-fold higher than in provincial schoolchildren (4.13 ± 0.21 versus 1.18 ± 0.09 ng/m3; P < 0.001 and 1.50 ± 0.12 versus 0.43 ± 0.05 ng/m3; P < 0.001, respectively). The concentration of urinary 1-hydroxypyrene (1-HOP) was significantly higher in Bangkok schoolchildren. Bulky carcinogen-DNA adduct levels in peripheral lymphocytes were also significantly higher (0.45 ± 0.03 versus 0.09 ± 0.00 adducts/108nt; P < 0.001). Finally, a significantly higher level of DNA strand breaks and a significantly lower level of DNA repair capacity were observed in Bangkok schoolchildren (P < 0.001). This study indicates that Bangkok schoolchildren exposed to a high level of genotoxic PAHs in ambient air may be more vulnerable to the health impacts associated with the exposure to genotoxic pollutants than children in provincial areas and may have increased health risks for the development of certain diseases such as cancer. © 2007 Oxford University Press.