Publication: Anti-HIV and cytotoxic biphenyls, benzophenones and xanthones from stems, leaves and twigs of Garcinia speciosa
Issued Date
2018-03-01
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00319422
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2-s2.0-85039852589
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytochemistry. Vol.147, (2018), 68-79
Suggested Citation
Phanruethai Pailee, Chutima Kuhakarn, Chanyapat Sangsuwan, Sakchai Hongthong, Pawinee Piyachaturawat, Kanoknetr Suksen, Surawat Jariyawat, Radeekorn Akkarawongsapat, Jitra Limthongkul, Chanita Napaswad, Palangpon Kongsaeree, Samran Prabpai, Thaworn Jaipetch, Manat Pohmakotr, Patoomratana Tuchinda, Vichai Reutrakul Anti-HIV and cytotoxic biphenyls, benzophenones and xanthones from stems, leaves and twigs of Garcinia speciosa. Phytochemistry. Vol.147, (2018), 68-79. doi:10.1016/j.phytochem.2017.12.013 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44809
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Title
Anti-HIV and cytotoxic biphenyls, benzophenones and xanthones from stems, leaves and twigs of Garcinia speciosa
Author(s)
Phanruethai Pailee
Chutima Kuhakarn
Chanyapat Sangsuwan
Sakchai Hongthong
Pawinee Piyachaturawat
Kanoknetr Suksen
Surawat Jariyawat
Radeekorn Akkarawongsapat
Jitra Limthongkul
Chanita Napaswad
Palangpon Kongsaeree
Samran Prabpai
Thaworn Jaipetch
Manat Pohmakotr
Patoomratana Tuchinda
Vichai Reutrakul
Chutima Kuhakarn
Chanyapat Sangsuwan
Sakchai Hongthong
Pawinee Piyachaturawat
Kanoknetr Suksen
Surawat Jariyawat
Radeekorn Akkarawongsapat
Jitra Limthongkul
Chanita Napaswad
Palangpon Kongsaeree
Samran Prabpai
Thaworn Jaipetch
Manat Pohmakotr
Patoomratana Tuchinda
Vichai Reutrakul
Other Contributor(s)
Abstract
© 2017 Elsevier Ltd Eleven previously undescribed compounds, including four benzophenones (garciosones A−D), four xanthones (garciosones E−H) and three biphenyls (garciosines A−C), along with eighteen known compounds were isolated from the stems, leaves and twigs of Garcinia speciosa Wall. (Clusiaceae). Their structures were established by extensive spectroscopic analysis. For garciosines A−C, the structures were confirmed by single crystal X-ray diffraction analysis. Most of the isolated compounds were evaluated for their cytotoxic activity and anti-HIV-1 activity using the syncytium inhibition assay and HIV-1 reverse transcriptase (RT) assay. The known compounds, 4,6,3′,4′-tetrahydroxy-2-methoxybenzophenone and macluraxanthone, displayed significant cytotoxic activity with the ED50 in the range of 1.85–11.76 μM. 1,5-Dihydroxyxanthone exhibited the most potent anti-HIV activity against syncytium formation with EC50 < 17.13 μM (SI > 25.28) and 2-(3,3-dimethylallyl)-1,3,7-trihydroxyxanthone was the most active compound in the HIV-1 reverse transcriptase assay with IC50 value of 58.24 μM. Structure-activity relationship of some isolated compounds were also discussed.